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Mostrando ítems 40546-40565 de 41985
Uncivering mechanisms of acquired resistance to trastuzumab-emtansine (T-DM1) in HER2 positive breast cancer
Trastuzumab-emtansine (T-DM1) is an antibody-cytotoxic agent (DM1) conjugated drug. DM1 delivery by trastuzumab inside the HER2 positive cells affects microtubule polymerization, cell cycle arrest and finally cell death. ...
Uncovering a novel function of the exonuclease Xrn1 in viral and cellular mRNA translation
The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation initiation of BMV RNA. ...
Uncovering novel vulnerabilities of melanoma cells based on RNA regulation
La tesi doctoral aquí presentada busca entendre quin és el paper de les proteïnes d’unió a l’ARN en la progressió tumoral, ja que s’ha demostrat que aquestes proteïnes poden regular aspectes que permeten o inhibeixen la ...
Uncovering REDD+ readiness in Mexico: Actors, discourses and benefit-sharing
La Reducción de Emisiones por Deforestación y Degradación forestal, además de la conservación, el manejo sostenible de bosques y aumento de reservas de carbón forestal (REDD+) es un mecanismo de política internacional que ...
Uncovering the Dynamic, Cognitive, and Linguistic Strategies of Misinformation
Les mentides, la manipulació o la informació falsa no són res de nou. Totes han existit durant segles des que el flux i el contingut de la informació ha estat una font de poder. Tot i això, a l'era de les plataformes ...
Uncovering the elements that regulate IKKalpha function in response to DNA damage
[spa] La terapia actual contra la mayoría de los cánceres está basada en el uso de agentes que dañan el ADN, como la quimioterapia o la radioterapia, que erradican las células tumorales proliferantes. Desafortunadamente, ...
Uncovering the functional organization of molecular interaction networks using network embeddings based on graphlet topology
[eng] For this purpose, Spatial Analysis of Functional Enrichment (SAFE) framework was proposed to uncover functional regions in a network by embedding it in 2-dimensions (2D) using the Spring embedding algorithm. However, ...
Uncovering the interplay between call fate specification and progenitor dynamics during the development of the lower rhombic lip
The Lower Rhombic Lip (LRL) is a transient neuroepithelial structure of dorsal hindbrain that gives rise to deep brainstem nuclei like the vestibular, auditory and precerebellar nuclei. In this work, we have followed the ...
Uncovering the large-scale effects and mechanisms of brain disease through whole-brain computational modeling
The activity of the brain at rest reveals an intricate functional architecture and yet, the underlying mechanisms generating it are still not well understood. Whole-brain computational models have turned into fundamental ...
Uncovering the Mechanistic Scenarios of Nucleophilic Couplings in Cp*Co Systems
El desenvolupament de metodologies sintètiques eficients per a la construcció de molècules complexes ha estat una àrea destacada d'investigació en les últimes dècades. L'activació selectiva dels enllaços C–H, promoguda ...
Uncovering the molecular and cellular mechanisms of metastatic dormancy in luminal breast cancer
Breast cancer (BC) is the most common cancer in women and it represents the most common cause of cancer-‐related death in women worldwide1. Advances in early detection, prevention, risk stratification, and therapeutic ...
Under the Net
Iris Murdoch es una escritora inglesa que tuve el diagnostico de la Enfermedad de Alzheimer (EA) confirmado sea por exámenes clínicos o por el diagnostico histológico post mortem. Por esta razón sus libros se tornaron una ...
Underdrain design and operational conditions in sand media filters using reclaimed effluents in drip irrigation systems
At present, agriculture is the human activity which requires more volume of water. Given the importance and scarcity of this resource, the efficient use of water has become a priority. On one hand, if possible, it is ...
Understanding a new tourism market and destination development: The case of Chinese tourism in Spain
El crecimiento del turismo chino hasta ser el primer emisor mundial de turismo es uno de los fenómenos más excitantes que ha ocurrido en los últimos años. Sin embargo, entender al turista chino supone un desafío en destinos ...
Understanding Acetylcholinesterase Inhibitors: Computational Modeling Approaches
La presente Tesis Doctoral constituye un estudio teórico sobre el proceso de inhibición de la acetilcolinesterasa por moléculas que bloquean el sitio activo de la proteína. Se han estudiado un conjunto de 44 inhibidores, ...
Understanding Agricultural Change: Integrated analysis of societal metabolism at different scales
La industrialización de los sistemas rurales y la integración en los mercados internacionales son estrategias de desarrollo rural comúnmente propuestas en países del Sur. El modelo tecnificado de la agricultura ha provocado ...
Understanding alternative splicing using deep mutagenesis
Alternative pre-mRNA splicing is a regulated step in eukaryotic gene expression in which introns are removed from the transcript and exons are joined together to form a mature mRNA. To study the effects of mutations on ...
Understanding and addressing the support needs of young adults with autism: the creation and implementation of a program to develop self-determination
El desenvolupament de autodeterminació és clau en les persones amb i sense discapacitat. Aquesta afavoreix millors resultats després de l’educació obligatòria, i ajuda a millorar la qualitat de vida general. Les persones ...
Understanding and Exploiting Almond Genetic Diversity for Peach Breeding: Development of a Peach-Almond Introgression Line collection and Fine Mapping of Key Fruit-Related Genes
El presseguer (Prunus persica), un dels arbres fruiters més importants, té baixos nivells de variabilitat genètica. Una manera d’augmentar la seva diversitat és mitjançant la introducció d’al·lels nous d’altres espècies ...
Understanding and mitigating the post-injection seismicity induced by fluid injection in enhanced geothermal systems
(English) Induced seismicity due to hydraulic stimulation and circulation is a hurdle for the development of Enhanced Geothermal Systems (EGS). The monitored seismicity has occasionally reached magnitudes large enough to ...
