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Now showing items 5885-5904 of 42454
Characterization of new mutations in transferrin, DMT1 and SEC23B causing rare iron metabolism-related diseases; and the discovery of RACGAP1 as the gene responsible for autosomal recessive congenital dyserythropoietic anaemia type III
Iron is a biometal involved in many physiological processes that are essential for life. Iron metabolism is a complex and tightly regulated process both at the systemic and cellular level. Proper iron homeostasis relies ...
Characterization of non-Saccharomyces wine yeasts during desiccation stress imposition
L’objectiu principal d’aquest estudi és la caracterització fisiològica de llevats vínics no-Saccharomyces sota l’estrès de deshidratació. Actualment, els Llevats Vínics Secs Actius (LVSA) són extensament usat per la producció ...
Characterization of novel actionable molecular subgroups in Hepatocellular Carcinoma: Immune class and IGF2-driven tumors
Insulin-like growth factor (IGF) signaling is frequently altered in HCC, including activation of IGF1R, IGF2 overexpression, IGFBP3 downregulation and IGF2R allelic losses1,2. A previous study from our group identified ...
Characterization of novel Hhex partners: SOX13 and c-Myc. New mechanism for the regulation of Wnt/TCF and c-Myc pathways
Hhex transcription factor is expressed in multiple endoderm-derived tissues, like the liver, where it is essential for proper development. The pleiotropic effect of Hhex in the embryo and its dual role as a transcriptional ...
Characterization of Oenococcus oeni and other lactic acid bacteria from the vine-wine ecosystem in Priorat
Oenococcus oeni, l’espècie de bacteris làctics (BL) principal responsable de la fermentació malolàctica (FML), s'ha aïllat repetidament dels vins, però quasi mai des del raïm. En aquesta tesi, la biodiversitat de BL de ...
Characterization of pathogenic immune mechanisms in oligoarticular juvenile idiopathic arthritis applying single-cell transcriptomics and proteomics
L'artritis idiopàtica juvenil (AIJ) és una malaltia reumàtica prevalent en nens, que comprèn set subtipus diferents. El subtipus més comú és l'AIJ oligoarticular (AIJo), que representa entre el 30 i el 60% de tots els ...
Characterization of plant cellular responses upon pathogen-induced RNA silencing suppression
que regular la producción de distintos efectores para explotar completamente al huésped en su propio beneficio. El silenciamiento génico mediado por ARN es un mecanismo de defensa antiviral y, como tal, está sometido a ...
Characterization of pneumonia among children under five years of age hospitalized in Thimphu, Bhutan
[eng] The general objective of this thesis was to describe the epidemiology, aetiology, clinical presentation, and radiological findings of pneumonia among Bhutanese children to better characterize childhood pneumonia in ...
Characterization of polymers and Microencapsulated Phase Change Materials used for Thermal Energy Storage in buildings
The use of renewable heat decreases the consumption of fossil resources, although its usage is intermittent and usually does not match the demand. A proper thermal energy storage system design can eliminate this problem ...
Characterization of resistant Cucumis germplasm to manage root-knot nematodes Meloidogyne spp.
Plant resistance through grafting susceptible scions onto resistant rootstocks is an effective measure to supress root-knot nematode (RKN) populations and to reduce crop yield losses. However, the reiterative use of specific ...
Characterization of Rpn10 monoubiquitination as a novel way of proteasome regulation
Targeted protein degradation plays a central role in eukaryotic cell regulation and homeostasis. The ubiquitin proteasome system (UPS) is involved in a large number of cellular events, being, day by day, more difficult to ...
Characterization of s-oxidizing biomass through respirometric techniques under anoxic and aerobic conditions
La monitorització de l’activitat biològica en biofiltres percoladors és complexa ja que implica l’estimació de la concentració de biomassa i el rendiment de creixement. Aquestes dades no són senzilles de calcular quan ...
Characterization of seawater intrusion and submarine groundwater discharge in al luvial coastal aquifers: field and laboratory approach
Seawater intrusion (SWI) causes not only salinization of coastal aquifers, but also a reduction submarine groundwater discharge (SGD) and nutrient fluxes to marine ecosystems. We have developed a small scale experimental ...
Characterization of sexual commitment and the early steps of sexual development in the human malaria parasite Plasmodium falciparum
Transmission of malaria requires that some parasites abandon asexual replication and develop into sexual stages termed gametocytes. The discovery of the transcription factor PfAP2-G as the master regulator of sexual ...
Characterization of SF3B1 mutation in chronic lymphocytic leukemia and the role of new splicing modulators
Mutations in Splicing Factor 3b Subunit 1(SF3B1) are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with worse disease prognosis. SF3B1 is involved in pre-mRNA splicing and is the ...
Characterization of simple and complex genomic structural variation : a study of human populations and leukaemia
Over the last ten years, improvements in molecular techniques and the arrival of the next-generation sequencing technologies have revealed a large amount of structural variation (SV) in the human genome. Consequently, there ...
Characterization of snail1 and pten transcriptional regulation by snail1: New insights into epithelial-to-mesenchymal transition and cell resistance to apoptosis
The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...
Characterization of Spatial Heterogeneity in Groundwater Applications
La heterogeneidad es una característica saliente de cada formación geológica natural. En las últimas décadas un gran número de trabajos se han centrado en estudiar la influencia de la heterogeneidad en los problemas de ...
Characterization of synthetic lethality between MYC activation and splicing inhibition in an immortalized cell line : roles of alternative splicing
Cancer cells exhibit a synthetic lethal (SL) phenotype when Myc upregulation is combined with antitumor drugs targeting the splicing factor SF3B1. However, the molecular events and mechanisms responsible for this vulnerability ...
Characterization of the 5-HT(7) receptor as a new therapeutic target for the treatment of pain
The work showed in this Thesis has been part of the “5-HT7 and neuropathic pain” project in the pharmaceutical company Esteve. Thus, the aim of this Thesis was in line with the goal of the 5-HT7 project at Esteve, focused ...
