Universitat de Barcelona
Mostrando ítems 10201-10220 de 11252
El receptor de glucocorticoides (GR) es un factor de transcripción que se expresa de forma ubicua y controla procesos esenciales para la vida como el metabolismo, la inflamación y la homeostasis. Aunque se han publicado ...
Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a positive sense single ...
Objectives: Objective 1 – Effect of mutations perturbing the ULBR of the Unique domain of c-Src. The first objective of this thesis was the in vitro characterization of the effect of mutations in the ULBR on the ...
Traumatic Brain Injury (TBI) can be defined as an alteration in brain function or evidence of brain pathology caused by an external force. In this thesis the focus of attention is on brain diffuse axonal injury (DAI). DAI ...
The balance between proteolytic and antiproteolytic activity is crucial in many biological processes such as nutrition, immune defence, virulence and tissue remodelling. Therefore, it is controlled by several mechanisms, ...
Mediterranean species have to be in constant acclimation to seasonal environmental changes, including variations in water availability, air temperature and solar radiation. Due to global warming, these environmental changes ...
La enfermedad de Parkinson (EP), la enfermedad de Parkinson con Demencia (EPD) y la Demencia con Cuerpos de Lewy (DCL) presentan una alteración del metabolismo de la alfa-sinucleína que provoca la formación de agregados ...
Alzheimer’s disease (AD) is the most common form of dementia. It was first described in 1906 by Alois Alzheimer. Later on, in 1984 George Glenner and Colin Masters isolated the amyloid-beta (Aβ) peptide from a human brain ...
The Escherichia coli infecting T7 bacteriophage shares a common dsDNA packaging mechanism with other bacteriophages of the Caudovirales order, Herpesviruses and Adenoviruses. The packaging machinery comprises the portal ...
[spa] La espondiloartritis axial (EspAax) es una enfermedad inflamatoria crónica con síntomas predominantemente axiales, cursa con inflamación predominantemente en les articulaciones sacroilíacas y en la columna. Una de ...
The last half of twentieth century has witnessed a key shift in the production process of knowledge: the most important discoveries and innovations in science and technology are not anymore the result of the work of very ...
[eng] Aqueous zinc ion batteries (AZIBs) have garnered significant research attention due to their remarkably high-volume energy density, reaching up to 5,851 mAh mL-1. This surpasses the capabilities of state-of-the-art ...
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels proteins for a variety ...
[eng] Cholera is an acute life-threatening infection caused by the bacterium Vibrio cholerae, a devastating pathogen in least developed countries, which caused six world pandemics, apart from the ongoing one. Despite current ...
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured negatively charged ...
Proteins are large biomolecules that play essential functional and structural roles within cells and that typically act through their interaction with other proteins and biomolecules, forming highly specific functional ...
Biological membranes (BMs) are self-sealing boundaries, which confine the permeability barriers of cells and organelles and provide the means to compartmentalize functions. Apart from being crucial for the cell structure, ...
Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, and few computer ...
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide bridge. Genetic defects ...
The present thesis is divided in three different but related projects. In the first project, the interaction between TGIF1 and SMAD proteins is investigated. TGIF1 is a transcriptional suppressor that prevents the gene ...
