Universitat de Barcelona
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La ubiquitinació és una modificació postraduccional de proteïnes empleada en la regulació de molts tipus diferents de senyalitzacions cel·lulars i processos biològics. Els enzims responsables d'aquesta modificació ...
Oxidative stress is one of the most important factors in degenerative diseases like cancer, Alzheimer or in episodes like ischemia. During these processes, reactive species of oxygen (ROS) and nitrogen (RNS) are generated. ...
Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology field. In this ...
The aim of this thesis was to study the function and regulation of two of the major players in the carbohydrate metabolism regulated by insulin, the facilitative glucose transporters GLUT2 and GLUT4, in teleost fish. In ...
The short-tailed opossums of the genus Monodelphis Burnett, 1830 are small-bodied semifossorial marsupials which inhabit almost all major biomes of South America up to 2200 m. Even though it is one of the most speciose ...
Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact ...
The present research project can be included in the broad supramolecular chemistry field that was defined by Nobel laureate Jean Marie Lehn as the "chemistry beyond the molecule".1 It is based on processes of molecular ...
The term light pollution refers to different harmful effects produced by artificial light sources. This phenomena affects observational astronomy, the flora and fauna of the species adapted to the natural cycles of light ...
[eng] Enhancers are the master regulators of gene expression. Genes rely on them to be differentially expressed in different tissues, developmental time points or contexts. In recent years, it has been reported that although ...
Adaptive optics (AO) systems are used to increase the spatial resolution achieved by ground-based telescopes, which are limited by the atmospheric motion of air layers above them. Therefore, the real cut-off frequency is ...
The Levant, and Israel in particular, possesses a rich archaeological record of prehistoric caves from the Middle and Upper Paleolithic periods. Some of these caves have been subjected to intensive multidisciplinary studies, ...
This thesis is divided in different sections. After a short introduction about the thesis contents, the theory chapter presents the Standard Model of Particle Physics (SM), with an emphasis on those properties of flavour ...
Current lifestyle with high-energy diets and little exercise is triggering an alarming growth in obesity. Excess of adiposity is leading to severe increase in associated pathologies, such as insulin resistance, type ...
Cells in tissues are exposed to extracellular signals that integrate and appropriately translate into specific responses. Receptors at the cell membrane recognize a variety of soluble ligands, extracellular matrix proteins ...
Cell migration is essential to many biological processes. In adult organisms, it is crucial for wound healing, homeostasis, and immune response, whereas aberrant cell migration potentially leads to pathology. For example, ...
This thesis illustrates the work I have developed as a Ph.D. student in the computational genomics group lead by Dr. David Torrents at the Barcelona Supercomputing Center. The group’s expertise in the analysis of biological ...
Nowadays, serious concern exists about atmospheric CO2 increase related with environmental impact and climate change. The reuse of CO2 through its chemical recycling is a promising route, which could contribute to the ...
Neuroblastoma (NB) is the most common extracraneal solid tumor diagnosed in the first 5 years of childhood and accounts for approximately 15% of all pediatric cancer-related deaths. At the time of diagnosis, about half of ...
[eng] G-quadruplexes are non-canonical DNA structures that appear in Guanine-rich oligonucleotides. Four Guanines interact through Hoogsteen hydrogen bonds forming a tetrad which is stabilized by metallic ions. Two or more ...
[eng] MECP2 is a multifunctional gene involved in multiple processes such as transcription regulation, chromatin remodelling, splicing and miRNA regulation. Malfunction of MECP2 due to loss of function mutations leads to ...
