Universitat de Barcelona
Now showing items 10201-10220 of 11095
[eng] In this thesis, I investigate different synaptic and circuit mechanisms of working memory, how their interaction produces specific working memory biases, and how their disruption in psychiatric or neurological disease ...
The cerebral cortex is organized in complex circuits of neurons strongly interconnected in a conductive medium. During deep sleep stage, this neuronal connectivity generates recurrent synchronized synaptic activity leading ...
Synapses are the contact sites where the transfer of information from the presynaptic to the postsynaptic site occurs. Correct processing of information requires that synapses continuously adapt their properties to an ...
Modern oncology conceives solid tumours as organs by themselves, meaning that not only should the behaviour of cancer cells to be considered and evaluated therapeutically, but also the so-called tumour microenvironment. ...
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due to their ability ...
Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles in human physiology ...
The thesis consists of two main projects: a) the development of a novel strategy to gain genetic control with spatiotemporal precision, and b) the optimisation of inhibitors of the protein kinase p38α, which has a major ...
Malaria is a parasitic disease caused by Plasmodium parasites and it is transmitted by female Anopheles mosquito. P. falciparum has a complex life cycle that includes important stages in two different hosts: a mosquito and ...
Nowadays, Nanotechnology is having an impact on practically every aspect of human life. It is a transformative technology that has influenced and will continue on electronics, computers, medicine, catalysis, energy, and ...
The concept of nanotechnology is attributed to Nobel prize winner Richard Feynman who gave a very famous, visionary in 1959 (published in 1960) during one of his lectures, saying: "the principles of physic, as far as I can ...
The goal of the present investigation is to examine the processing-structure-property relationships of multilayer graphene nanowall materials. Various plasma enhanced chemical vapor deposition (PECVD) processing parameters ...
[eng] Nanostructured semiconductors have gained significant importance due to their size- and morphology-tunable physical properties, and their ability to play a critical role in various fields such as energy conversion ...
The present Thesis is divided in three chapters: 1. Design and synthesis of new soluble epoxide hydrolase inhibitors (sEHI) The synthesis of new soluble epoxide hydrolase inhibitors based on ureas as the main ...
In the present thesis Supramolecular chemistry is exploited to approach applications in the area of Nanomedicine, and it is, focused on the design and preparation of different micro and nanotools for sensing and therapy, ...
[eng] The present Thesis is entitled “Synthesis and Magnetic Studies of Quasi-Isotropic Coordination Compounds with 3d and 4f cations”. The topic of the Thesis is to prepare coordination compounds of paramagnetic metal ...
[eng] My thesis was part of a collaborative project at the interface of neuropharmacology and medicinal chemistry that aimed to better understand the neuromodulation mechanisms associated with Alzheimer’s Disease (AD). In ...
Over the past decade, sphingolipids have emerged as a new class of modulators of various cell functions. Ceramide, which is the central molecule in the biosynthesis of sphingolipids and glycosphingolipids, is involved in ...
As an essential resource for life and most human activities, water resources protection have become one of the major focuses of scientific community, especially the increasing occurrence of emerging pollutants which have ...
[eng] Visible-light photocatalysis is currently one of the hottest research areas in organic chemistry, due to the possibility that offers to form C-C and C-Het bonds in a green, non-toxic and efficient way. Although ...
Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...
