Universitat de Barcelona
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La ICSI és una tècnica de reproducció assistida molt eficient, però la fallada de fecundació (FF) pot ocórrer en un 1-3% dels cicles. La FF té un elevat impacte en els pacients i és molt difícil de predir, diagnosticar i ...
The main goal of this thesis was to investigate the function of the endogenous CD300f. Initially, CD300f was described as an inhibitory receptor, although some data generated in our lab strongly suggested the possibility ...
Adenosine and dopamine receptors are members of the GPCRs family for which a significant segregation between their A2A and D2 subtypes has been demonstrated in the GABAergic striopallidal neurons of the basal ganglia. In ...
La capacidad de <i>Acinetobacter baumannii</i> para causar infecciones nosocomiales se relaciona con su habilidad para desarrollar rápidamente resistencia a los antibióticos, junto con la capacidad que tiene este organismo ...
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate different ...
[eng] 1. HYPOTHESES. Primary liver cancer is the sixth most commonly diagnosed cancer and the second leading cause of cancer-related death worldwide2,3. Around 90% of cases correspond to hepatocellular carcinoma (HCC)2,3, ...
Carnitine palmitoyltransferase 1 (CPT1) catalyzes the conversion of long chain fatty acyl-CoAs into acylcarnitines, the first step in the transport of long chain fatty acids from the cytoplasm to the mitochondrial matrix, ...
[eng] BACKGROUND: High-risk neuroblastoma (NB) represents a heterogeneous group of tumors, whereby patients can display response to treatment and long-term outcome or develop early progressive, chemoresistant disease with ...
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...
[spa] El cáncer hepatobiliar (incluye principalmente el carcinoma hepatocelular [HCC] y el cáncer del tracto biliar [BTC]) representa la tercera causa de muerte relacionada con cáncer en todo el mundo [1]. Menos de la mitad ...
[eng] The hypothesis underlying the AMBAR study research seeks to evaluate the clinical efficacy of PE, in combination with albumin and intravenous immunoglobulin replacement (IVIG), as a treatment for Alzheimer's disease ...
Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of these couples will ...
Kv1.3 plays a crucial role in leukocytes, where it regulates activation and proliferation. In these cells, Kv1.3 is coexpressed with modulatory subunit KCNE4. This ancillary peptide acts as a dominant negative regulator ...
[spa] La expresión genética es un proceso celular clave, que además está relacionado con la susceptibilidad genética a enfermedades y rasgos complejos. La mayoría de genes se someten a splicing alternativo (AS). Las variantes ...
Metallothioneins (MTs) are a superfamily of ubiquitous and small cysteine rich metalloproteins present in all eukaryotes and some prokaryotes organisms, that exhibit preferences to coordinate divalent or monovalent heavy ...
INTRODUCTION: For decades it was known that many species contain embryo specific linker histone H1 variants that replace the somatic H1 during early embryogenesis. This is especially important because the early embryo ...
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
