Browsing Universitat de Barcelona by Title

Synthesis, structural elucidation and biological evaluation of Pipecolidepsin A and Phakellistatin 19

Pelay Gimeno, Marta (Date of defense: 2013-02-15)

Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...

Synthetic approaches towards organic products of pharmaceutical interest

Jora, Beatrice Elena (Date of defense: 2022-10-27)

[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are very old, therefore ...

Synthetic engineering of membrane transport to increase photosynthesis and water use efficiency = Enginyeria sintètica del transport de membrana per tal d’augmentar la fotosíntesi i l’eficiència en l’ús de l’aigua

Minguet Parramona, Carla (Date of defense: 2015-12-11)

The rapid increase on world’s population is threatening food security, mainly in developing countries, where poverty and hunger are already a big concern. However, a growth in agriculture generates an overall economic ...

Synthetic Polymyxin-based Peptides Against Multidrug Resistant Bacteria: A Therapeutic Option

Rudilla Mateo, Héctor (Date of defense: 2019-01-18)

Pseudomonas aeruginosa and Staphylococcus aureus are nosocomial opportunistic pathogens causing a wide variety of both acute and chronic infections, such as pneumonia, bacteraemia, and urinary tract infections. Immunocompromised ...

System building : estudio etnográfico de los proyectos de investigación de la School of Computer Science de Carnegie Mellon University, un "computer-intensive campus" norteamericano

Serra Hurtado, Arturo (Date of defense: 1992-01-01)

Esta tesis consiste en una etnografía de la cultura informática de investigación de la Carnegie Mellon University, desarrollada mediante un trabajo de campo de dos años en la School of Computer Science de dicha universidad ...

A systematic and comprehensive approach for large-scale genome-wide association studies. Unraveling non-additive inheritance models in age-related diseases

Guindo Martínez, Marta (Date of defense: 2019-12-18)

Genome-wide association studies (GWAS) have been proven useful for identifying thousands of associations between genetic variants and human complex diseases and traits. However, the identified loci account for a small ...

Systematic characterization of the genome-wide and nuclear distribution of six linker histone H1 variants in human cancer cells

Salinas Pena, Mónica (Date of defense: 2023-09-20)

[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous H1 variants in T47D ...

Systematic identification and quantification of substrate specificity determinants in human protein kinases = Identificación y cuantificación sistemática de determinantes de la especificidad por sustrato en las proteínas quinasas de humano

Alonso Tarajano, Manuel Alejandro (Date of defense: 2013-10-24)

In human there are 518 protein kinases reported and many of them are involved in several cellular processes and also in important pathologies. Kinases have a diverse specificity for the sequences they phosphorylate, and ...

Systematics and historical biogeography of the genus Dugesia (platyhelminthes, Tricladida)

Solà Vàzquez, Eduard (Date of defense: 2014-07-15)

Dugesia is a genus of free-living flatworms which species inhabit freshwater bodies across a wide distribution range that includes Africa, Madagascar, Eurasia and Australasia. They do not survive in salt water or under ...

Systematics of Nearctic and Neotropical Oak Gall Wasps (Hymenoptera: Cynipidae: Cynipini), with a focus on specific genera in the fauna of Mexico

Cuesta Porta, Victor (Date of defense: 2023-11-13)

[eng] The oak gall wasps (Hymenoptera: Cynipidae: Cynipini) are a group of specialized endophytophagous microhymenopterans that induce galls on Fagaceae trees, principally oaks (Quercus L.). The systematics of this tribe ...

Systematics, biogeography and evolution of selected widespread reptile genera from the arid areas of North Africa and Arabia

Metallinou, Margarita (Date of defense: 2014-07-17)

The arid areas of North Africa and Arabia cover a surface of more than 13 million square kilometers and are characterized by their extreme temperatures, diversity of desert habitats and well-adapted flora and fauna. The ...

A Systems Medicine approach to multimorbidity. Towards personalised care for patients with Chronic Obstructive Pulmonary Disease

Tényi, Ákos (Date of defense: 2018-07-13)

BACKGROUND: Multimorbidity (i.e. the presence of more than one chronic disease in the same patient) and comorbidity (i.e. the presence of more than one chronic disease in the presence of an index disease) are main sources ...

Systématique et Phylogénie de Plathelminthes parasites ("Trematoda et Cestoda"): apport des études ultrastructurales de la reproduction

Ndiaye, Papa Ibnou (Date of defense: 2003-09-30)

El presente estudio constituye una importante contribución al conocimiento de la ultraestructura de la espermiogénesis y del espermatozoide de los Platelmintos parásitos. Los caracteres ultraestructurales de la reproducción, ...