Athanasiadis, Georgios (Date of defense: 2010-07-14)
In this work we have analyzed the variation of (i) several X chromosome polymorphic Alu insertions and (ii) several SNPs and microsatellites within and around the genomic regions of the genes coding for ...
Louzao Boado, Ánxela (Date of defense: 2019-04-30)
Genetically tractable models such as Drosophila melanogaster may help to identify new approaches to halt malignant growth. During my doctoral thesis, I performed a screen to find mitochondrial genes ...
Castro i Català, Marta de (Date of defense: 2017-09-22)
Schizophrenia is a severe and complex mental disorder that results in an inability to cope with life’s ordinary demands and routines. Normally, it appears in late adolescence, more frequently and ...
Roura Frigolé, Helena (Date of defense: 2018-07-27)
Adenosine deaminase acting on transfer RNA (ADAT) is a human heterodimeric enzyme that catalyzes the deamination of adenosine (A) to inosine (I) at the first position of the anticodon of transfer RNAs ...
Popa, Crina Mihaela (Date of defense: 2015-10-16)
The soil-borne plant pathogen Ralstonia solanacearum is the causing agent of bacterial wilt, a devastating disease of wide geographical distribution and host range with enormous economic impact worldwide. ...
Burguera Hernández, Demian (Date of defense: 2017-09-22)
In the present work, we studied the evolution of alternative splicing (AS) from different perspectives. First, we performed a preliminary analysis where we identified alternative exons with tissue-specific ...
Gomez Grau, Marta (Date of defense: 2015-12-18)
Lysosomal storage disorders (LSDs) are a group of more than 50 different genetic disorders due to the lack of degradation of substrates within lysosomes. Most of them are caused by mutations in genes ...
Álvarez Fernández, Carmen (Date of defense: 2013-04-26)
This thesis is based on a genomic study of the epithelial fusion and wound healing processes using Drosophila melanogaster as a model system. The aimed of the work is to study the genomic differences ...
Cornet Bartolomé, David (Date of defense: 2019-07-09)
Infertility, defined by the World Health Organization (WHO) as the inability to conceive after a year of unprotected sex, is a disease that affects 1 in 9 couples of reproductive age worldwide. Most of ...
Sebé Pedrós, Arnau (Date of defense: 2013-06-07)
The origin of animal multicellularity is a major evolutionary transition and a poorly understood one. In recent years, the sequencing of the genomes of several earlybranching metazoans, such as sponges ...