Norris, Richard (Date of defense: 2021-10-13)
Insulinomas are extremely rare pancreatic neuroendocrine (PNET) tumours that develop from the β-cells of the pancreas.β-cells are the only cells capable of producing the hormine insulin, and play a major ...
Coll San Martín, Laia (Date of defense: 2021-11-29)
Cancer was reported as the second leading cause of death in 2018 by the World Health Organisation. Cancer is defined as the set of diseases that proceeds in multiple phases generating a transformation ...
Gómez Llonin, Andrea (Date of defense: 2021-04-30)
The application of NGS techniques to the study of mature B-cell neoplasms at the research level is providing a large amount of new information, in certain cases with clinical implications, which includes ...
Lafzi, Atefeh (Date of defense: 2020-05-29)
Single-cell RNA sequencing has revolutionized the way molecular mechanisms were being studied by allowing the dissection of gene expression at single-cell resolution. The data acquired from scRNA-seq ...
Benítez Álvarez, Lisandra (Date of defense: 2022-06-16)
Evolutionary Biology offers a set of methods and theories to elucidate the evolutionary processes that lead to the diversification of life. With the development of sequencing technologies, the access ...
Escuer Pifarré, Paula (Date of defense: 2022-12-21)
[eng] During the last decade, advances in high-throughput sequencing (HTS) technologies have increased exponentially the generation of genomic data, especially of non-model species. In this thesis, we ...
Solé Sánchez, Patricia (Date of defense: 2020-12-09)
[eng] Regulatory cells are essential to immune homeostasis. Both autoimmune diseases and the progression of cancer are related to alterations in the development and/or function of the regulatory ...
Atla, Goutham (Date of defense: 2021-05-05)
[eng] Diabetes mellitus is a heterogeneous group of metabolic diseases characterized by impaired blood glucose homeostasis that affects more than 415 million people worldwide and is a leading cause of ...
Mayayo Vallverdú, Clara (Date of defense: 2021-11-29)
[eng] Cystinuria, with a worldwide prevalence estimated at 1:7000, is a rare inherited disease characterized by urine hyperexcretion of cystine and dibasic amino acids. Its clinical manifestation is ...
Gracia Latorre, Elena (Date of defense: 2023-06-01)
[eng] Enhancers are the master regulators of gene expression. Genes rely on them to be differentially expressed in different tissues, developmental time points or contexts. In recent years, it has been ...