Ramos Rodríguez, Mireia (Date of defense: 2020-11-06)
Type 1 Diabetes (T1D) is a celltargeted autoimmune disease, leading to a reduction in pancreatic cell mass that renders patients insulindependent for life. In early stages of the disease, cells ...
Pitsili, Eugenia (Date of defense: 2021-11-04)
Metacaspases are a family of cysteine proteases found in lower eukaryotes and plants. They are considered to be distant relatives of caspases, present only in animals. The role of metacaspases is quite ...
Maric, Aida (Date of defense: 2021-11-05)
The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing ...
Rodríguez Muñoz, Laura (Date of defense: 2021-05-13)
The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor with key functions downstream of receptor tyrosine kinase (RTK)-Ras-MAPK signaling pathways. In both Drosophila and mammals, ...
Toulis, Vasileios (Date of defense: 2020-07-20)
The retina consists of several structured layers of highly specialized neurons that capture and process light stimuli enabling vision. Such a fine architecture turns retinal differentiation into an ...
Aísa Marín, Izarbe (Date of defense: 2022-05-13)
The transcription factor NR2E3 participates in photoreceptor cell fate determination as it functions as both transcriptional repressor of cone genes and activator of rod genes. Mutations in NR2E3 cause ...
Escribá Piera, Rubén (Date of defense: 2022-03-17)
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and a frequent cause of heart failure and sudden cardiac death. HCM is a highly complex condition defined by clinical and ...
Bonilla-Pons, Sergi A. (Date of defense: 2021-04-30)
Visual impairments and different retinopathies have been silently increasing in the modern society and they become a medical hurdle in need to be addressed. Müller glial cells (MGCs), in lower vertebrates, ...
De Giorgio, Ettore (Date of defense: 2022-03-18)
Chitin has a recognised importance in physiology but also as a biomaterial. In insects, it is the principal component of the apical extracellular matrix of epidermis, tracheae, foregut and hindgut. In ...
Catasús Segura, Núria (Date of defense: 2022-05-31)
Neurofibromatosis type 2 (NF2) is an autosomal dominant condition caused by loss of function variants in the NF2 gene. The pathognomonic feature of the disease is the development of bilateral vestibular ...