Vais, Ricardo Silva dos Santos (Date of defense: 2019-12-13)
The γ-‐tubulin ring complex (γTuRC) is required to efficiently generate new microtubules (MT) in a process known as MT nucleation. In mitotic cells, MT nucleation by γTuRC occurs from the centrosome, ...
Simões, Inês Tadeu dos Anjos (Date of defense: 2017-09-14)
Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- ...
Gutierrez Prat, Núria (Date of defense: 2018-10-03)
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate ...
González Tarragó, Víctor (Date of defense: 2019-07-11)
This thesis is a study on the integrin-mediated mechanoresponse by binding partners and force loading rates. Regarding the binding partners, here we demonstrate an alternative and counter-intuitive ...
López Pelegrín, Maria del Mar (Date of defense: 2015-11-13)
Metallopeptidases are major players in the physiology and pathology of all living organisms. Their exquisite regulation is therefore essential for proper function and to prevent misdirected temporal ...
Riba Moliner, Marta (Date of defense: 2015-12-11)
The focus of this thesis is the use of supramolecular chemistry to functionalize polymers to obtain organic-based materials with a control of their structure and properties. The non-covalent ...
Eftekharzadeh, Bahareh (Date of defense: 2015-04-16)
Spinal bulbar muscular atrophy (SBMA) is a rare hereditary neuromuscular disease caused by the elongation of a polymorphic polyglutamine (polyQ) tract in the N-terminal region of the transactivation ...
Toribio Isaías, Luis Daniel (Date of defense: 2019-12-18)
The aim of this project is to structurally characterize proteins involved in bacterial signal transduction systems by applying X-ray crystallography. Bacteria use signal transduction systems to react ...
Herrero Rodríguez, Laura (Date of defense: 2004-11-24)
INTRODUCTION Carnitine palmitoyltransferase I, which is expressed in the pancreas as the liver isoform (LCPTI), catalyzes the rate-limiting step in the transport of fatty acids into the mitochondria for ...
Diaz Garrido, Natalia (Date of defense: 2021-11-17)
The gut microbiota establishes dynamic and complex interactions with the intestinal epithelium and the immune system. In this regard, commensal microbiota plays essential role in the development and ...