Sola Lao, Irene (Date of defense: 2016-11-15)
This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and ...
Bhattacharyya, Mousumi (Date of defense: 2012-05-21)
Formation of a protein-ligand complex is opposed by the loss of rotational, translational and conformational degrees of freedom, but if the ligand binds in a conformation that does not corresponds to ...
Contreras Mostazo, Miriam Guadalupe (Date of defense: 2020-10-21)
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually ...
Cingolani, Francesca (Date of defense: 2015-07-10)
Sphingolipids (SLs), essential components of cell membranes, are bioactive molecules involved in the regulation of a variety of cellular processes. Ceramide and sphingosine generally mediate anti-proliferative ...
Abreu, Marcelle Silva de (Date of defense: 2018-07-24)
La pioglitazona (PGZ) es un agonista del peroxisoma proliferador activado del receptor gamma (PPARγ) receptor, pertenece a la clase de las tiazolidindionas y es usado para el tratamiento de la diabetes ...
Rachman, Moira (Date of defense: 2020-09-23)
Fragment-based drug design is an established strategy of finding new drugs. Instead of doing mass screening of chemical libraries containing compounds that are already lead-like, starting from a small ...
Torres Costa, Eva (Date of defense: 2013-09-30)
Research for new antivirals to treat Influenza A virus infections has gained importance during this last decade due to the imminent danger of an Influenza pandemic. For some years, several new strains ...
Novo de Oliveira, Ana Luísa (Date of defense: 2013-11-18)
The diversity of functional roles played by heme proteins in all kingdoms of life is to a large extent regulated by the thermodynamic and kinetic properties of their interaction with small gaseous ...
Pinto, Alexandre (Date of defense: 2017-09-28)
Chiral amino alcohol derived lactams are a valuable scaffold for the enantioselective synthesis of alkaloids. In the present thesis the potential of this methodology was expanded and to demonstrate the ...
Bosch, Caroline (Date of defense: 2016-10-21)
This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research ...