Rey Carrizo, Matías (Date of defense: 2014-11-28)
Influenza is a major health problem worldwide, as the periodic pandemics of the 20th century have highlighted. Some countermeasures have been developed and have indeed diminish the devastating effects ...
Ayats Rius, Carles (Date of defense: 2007-06-08)
Els compostos policíclics d'elevada simetria, a més del seu gran atractiu estètic i interès estructural, són substrats valuosos per a estudis mecanístics o bé com a intermedis en la síntesi de molècules ...
Torres Costa, Eva (Date of defense: 2013-09-30)
Research for new antivirals to treat Influenza A virus infections has gained importance during this last decade due to the imminent danger of an Influenza pandemic. For some years, several new strains ...
Barniol Xicota, Marta (Date of defense: 2017-01-13)
L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la ...
Muñoz Blasco, Mª Rosa (Date of defense: 2007-01-26)
Como continuación de los estudios realizados previamente por el grupo de investigación en el campo de los alquenos piramidalizados, en la presente Tesis Doctoral se ha realizado un estudio de generación, ...
Valverde Murillo, Elena (Date of defense: 2015-10-30)
For over eighty years, adamantane ring has interested organic chemists for its simplicity and symmetry. The rigid tricyclo[3.3.1.13,7]decane skeleton has provided a unique structural template for ...
Leiva Martínez, Rosana (Date of defense: 2017-09-22)
The present PhD Thesis evolves around the design, synthesis and pharmacological evaluation of novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Given that the enzyme active site ...
Codony Gisbert, Sandra (Date of defense: 2020-09-17)
Epoxieicosatrienoic acids acids (EETs) are endogenous chemical mediators derived from arachidonic acid that show anti-inflammatory, antihypertensive, analgesic, angiogenic and antiatherosclerotic effects. ...
Jora, Beatrice Elena (Date of defense: 2022-10-27)
[eng] The present thesis focuses on the study and synthesis of three active principles (APIs) with therapeutic activity. Although these compounds are commercially available, their route of synthesis are ...
Martín López, Juan (Date of defense: 2022-07-15)
The present Thesis is divided in three chapters: 1. Design and synthesis of new soluble epoxide hydrolase inhibitors (sEHI) The synthesis of new soluble epoxide hydrolase inhibitors based on ureas ...