Ara mostrant els elements 81-90 de 180
Silva, Rui Gonçalo Teixeira da (Data de defensa: 2022-09-16)
Steatotic livers are considerably more prone to IRI, in which turn, it is known to impair mitochondrial function. Our working hypothesis lies on the fact that impaired mitochondrial function and reduced ...
Ninfali, Chiara (Data de defensa: 2019-12-13)
Muscle atrophy, which is characterized by excessive protein catabolism, is one of the major adaptive processes that occur in several physiopathological and clinical conditions, to counteract stressing ...
González Burón, Helena (Data de defensa: 2014-03-19)
The human Tousled-like kinases 1 and 2 (TLKs) are predicted serine/threonine kinases that show maximal activity in S phase and are transiently inhibited by the DNA damage response (DDR). Both TLKs ...
Martín Liberal, Juan Jesús (Data de defensa: 2016-11-07)
Sarcomas are a group of malignancies characterized by their bad prognosis and the absence of effective treatments. Median survival of advanced sarcoma patients is only one year in spite of treatment. ...
Nadal Sanmartin, Cristina (Data de defensa: 2007-07-24)
1 INTRODUCCIÓN<br/><br/>El cáncer colorrectal (CCR) es la tercera causa de diagnóstico de cáncer en todo el mundo. El 11-27% de pacientes se diagnostican en estadio avanzado o metastático. De los ...
Palau de Miguel, Anna (Data de defensa: 2016-11-30)
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) ...
García Lizarribar, Andrea (Data de defensa: 2022-01-28)
In vitro engineered three-dimensional tissue models are attracting an increasing interest due to their potential applications in preclinical assays. On the one hand, they are an alternative to the high ...
Ortiz Barahona, Vanessa (Data de defensa: 2022-04-01)
The general aim of this thesis is to identify and characterize if there are DNA methylation patterns giving rise to cancer-related m5C RNA modification defects, potentially promoting malignant transformation ...
Ortega Cano, Juan Alberto (Data de defensa: 2011-09-30)
Brain derived neurotrophic factor (BDNF) is a chemokine which levels are regulated by neuronal activity and could act as a sensor in front of distinct physiologic stimulus, activating the transcription ...
Albert Colomer, Nerea (Data de defensa: 2021-01-18)
Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly ...