Bazzocco, Sarah (Date of defense: 2016-01-27)
Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of ...
Sanchez Moral, Lidia (Date of defense: 2019-11-22)
Multiple studies have highlighted the role of ZEB1 as critical regulator of tumor progression through the regulation of different hallmarks of cancer beyond the induction of EMT. The general aim of this ...
Muñoz Esquerre, Mariana (Date of defense: 2018-10-05)
INTRODUCCIÓN: La enfermedad cardiovascular, concretamente la cardiopatía isquémica es la enfermedad con mayor impacto en la morbimortalidad de los pacientes con EPOC, con independencia de otros factores ...
Oliveira Mateos, Cristina (Date of defense: 2020-06-16)
The vast majority of the human genome is transcribed giving rise to non-coding RNAs. Antisense transcripts are one of the most abundant types of long non-coding RNAs and many of them have regulatory ...
Bellmunt i Tarragó, Anna (Date of defense: 2017-12-15)
The identification of genes that mediate metastasis is pivotal to better understand the mechanism, to develop novel drugs and to stratify patients with highest risk and consecutively administrate them ...
Alba Garibay, Marco Antonio (Date of defense: 2014-11-07)
Giant cell arteritis (GCA) is a systemic vasculitis of unknown aetiology that affects medium-sized and large arteries. GCA may deeply impair the patient's quality of life as a result of systemic smouldering ...
Rofes Terrón, Paula (Date of defense: 2022-03-31)
The overarching aim of the present thesis project is to implement new testing strategies and develop new tools that will contribute to improve the genetic diagnosis of hereditary cancer, with the ultimate ...
Albero Gallego, Robert (Date of defense: 2017-07-21)
Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature B cells characterized by the presence of the t(11;14)(q13;q32) translocation that leads to the overexpression of Cyclin ...
Gómez Baldó, Laia (Date of defense: 2010-07-30)
Studies of the role of tuberous sclerosis complex (TSC) proteins (TSC1/TSC2) in pathology have focused mainly on their capacity to regulate translation and cell growth, but their relation with alterations ...
Canivell Fusté, Silvia (Date of defense: 2014-10-14)
The incidence of type 2 diabetes mellitus (T2D) is increasing worldwide. There are several explanations to this fact, such as the increased prevalence of obesity, population’s ageing, and the lack of ...