Mostrando ítems 31-40 de 972
Morén Núñez, Constanza (Fecha de defensa: 2012-04-11)
It is widely known that HIV and ARV drugs trigger mitochondrial impairment in adults. However, their effects in perinatally-infected children have been poorly explored. For this reason, the main hypothesis ...
Vegliante, Maria Carmela (Fecha de defensa: 2013-09-26)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified ...
Di Pietro, Ornella (Fecha de defensa: 2015-11-06)
The aim of this PhD thesis consists of the synergistic combination of both highly efficient synthetic approaches and molecular modelling tools for the structure-based drug design and synthesis of novel ...
Padrão, Gonçalo (Fecha de defensa: 2014-10-24)
To err is certainly human. Detect and correct our errors are fundamental during our interaction with the outside world. Therefore, understanding the nature of the brain mechanisms involved in the ...
Martínez Quetglas, Iris (Fecha de defensa: 2018-01-09)
Insulin-like growth factor (IGF) signaling is frequently altered in HCC, including activation of IGF1R, IGF2 overexpression, IGFBP3 downregulation and IGF2R allelic losses1,2. A previous study from our ...
Requena-Méndez, Ana (Fecha de defensa: 2016-03-29)
BACKGROUND For drug-compliant patients, poor responses to tuberculosis (TB) treatment might be attributable to subtherapeutic drug concentrations. An impaired absorption of rifampin and isoniazid was ...
Braga Pereira, Joana (Fecha de defensa: 2012-07-20)
Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder after Alzheimer’s disease (AD), affecting 100.000 people in Spain and more than 4 million people worldwide. Being ...
Spinosa, Vittoria (Fecha de defensa: 2019-12-16)
Perception can be considered as the bridge necessary to interact with the surroundings. Indeed, through our senses we are continuously exchanging information between the physical world around us and our ...
Herraiz Martínez, Adela (Fecha de defensa: 2016-12-20)
Background Ageing is a risk factor that promotes common cardiovascular diseases such as atrial fibrillation (AF) or heart failure (HF), which in turn are associated with pathological changes in ...
Nhampossa, Tacilta Helena Francisco (Fecha de defensa: 2013-12-20)
The objective of this thesis is to improve our understanding of the epidemiology of diarrhea, particularly to estimate the population-based burden, microbiologic etiology and adverse clinical consequences ...