Montal Roura, Robert (Date of defense: 2020-10-07)
[spa] El cáncer hepatobiliar (incluye principalmente el carcinoma hepatocelular [HCC] y el cáncer del tracto biliar [BTC]) representa la tercera causa de muerte relacionada con cáncer en todo el mundo ...
Serra Camprubí, Queralt (Date of defense: 2023-07-27)
[eng] The field of cancer treatment has shifted towards personalized medicine, driven by advancements in understanding molecular and genetic abnormalities and identifying specific targets within cancer ...
Súarez López, Lucía (Date of defense: 2013-07-05)
Durante la división celular, el ADN debe estructurarse en cromosomas para asegurar un correcto reparto de la información genética a las dos células hijas. El complejo condensina, junto con el motor ...
Martínez Redondo, Paloma (Date of defense: 2014-06-25)
The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded ...
Terribas Pérez, Ernest (Date of defense: 2016-01-20)
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 ...
Rodilla Martín, Ananda Marina (Date of defense: 2018-04-10)
Oral and lung cancer are included in the most prevalent respiratory diseases, being the latter one of the main causes of mortality worldwide. Despite new advances in diagnosis and clinical care, success ...
Fernández Alfara, Marcos (Date of defense: 2022-04-07)
Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling ...
Franco Valls, Héctor (Date of defense: 2022-05-26)
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast ...
Cortés Hinojosa, Marlies (Date of defense: 2017-05-26)
ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages ...
Moreno Cabrera, José Marcos (Date of defense: 2021-06-17)
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a ...