Fernández Alfara, Marcos (Date of defense: 2022-04-07)
Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling ...
Acevedo Lipes, Andrea Milena (Date of defense: 2021-03-09)
Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of ...
Cortés Hinojosa, Marlies (Date of defense: 2017-05-26)
ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages ...
Moreno Cabrera, José Marcos (Date of defense: 2021-06-17)
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a ...
Sallaberry Pinto, Júlia (Date of defense: 2019-03-22)
Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and ...
Aubets Gil, Eva (Date of defense: 2021-09-19)
This work is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as a gene silencing tool, and on the search of alternative methods for their delivery, including viral and non-viral ...
Esteve Arenys, Anna (Date of defense: 2017-12-22)
Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are ...
Recasens Zorzo, Clara (Date of defense: 2018-06-19)
Constitutive activation of the chemokine receptor CXCR4 is associated with tumor progression, invasion and resistance to treatment. Overexpression of CXCR4 in diffuse large B-cell lymphoma (DLBCL) confers ...
Guerrero Hernández, Martina (Date of defense: 2019-02-19)
The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation ...
Mazuelas Gallego, Helena (Date of defense: 2021-01-28)
Neurofibromatosis type 1 (NF1) is a genetic disease caused by inherited mutations in the NF1 gene. NF1 is a cancer predisposition syndrome, and the disease’s hallmark is the appearance of tumors of the ...