Ara mostrant els elements 11-20 de 122
Yoldi, Guillermo (Data de defensa: 2018-10-23)
The discovery that RANK signaling mediates the protumorigenic role of progesterone in the mammary gland and its association with poor prognosis in breast cancer has opened the possibility of using RANKL ...
Urruticoechea Ribate, Ander (Data de defensa: 2008-01-29)
DE LA TESIS:<br/><br/>El cáncer primario de mama es un problema de salud de gran magnitud con una incidencia estimada de 1 de cada 10 mujeres. De entre los tratamientos sistémicos, el tratamiento hormonal ...
Vidal Crespo, Anna (Data de defensa: 2017-04-28)
In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable ...
Aguilar Fadó, Esther (Data de defensa: 2015-02-23)
Metastasis represents the most life-threatening aspect of tumorigenesis and is the leading cause of death by cancer. Intensive research in this field has shed light on some of the molecular strategies ...
Zuazo Gaztelu, Iratxe (Data de defensa: 2018-11-23)
Tumor progression is a complex conundrum of events that involve not only tumor cells, but also their surrounding microenvironment. Accounting to the natural dependency of tumors on angiogenesis, its ...
Llorente Lope, Alicia (Data de defensa: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. ...
Monaco, Paola (Data de defensa: 2022-09-23)
[eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal ...
López Fauqued, Marta (Data de defensa: 2010-06-22)
Malignant melanoma is the most lethal skin cancer with no effective therapeutic treatment in its metastatic stages. RAS and PI3K pathways have been shown to play a critical role in melanoma development ...
Martínez Cartró, Míriam (Data de defensa: 2021-10-25)
Advances in structural and molecular biology have increased the knowledge of relevant and undrugged targets and have favoured the rational development of novel drugs through structure- based ...
Benítez, Sandra (Data de defensa: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...