Mostrando ítems 71-80 de 122
Serra Camprubí, Queralt (Fecha de defensa: 2023-07-27)
[eng] The field of cancer treatment has shifted towards personalized medicine, driven by advancements in understanding molecular and genetic abnormalities and identifying specific targets within cancer ...
Salinas Pena, Mónica (Fecha de defensa: 2023-09-20)
[eng] The histone H1 family comprises up to seven members in human somatic cells. However, H1 studies have been limited by the lack of specific ChIP-grade antibodies. Here, we have mapped six endogenous ...
Clua Villas, Anna (Fecha de defensa: 2023-07-17)
[eng] G-quadruplexes are non-canonical DNA structures that appear in Guanine-rich oligonucleotides. Four Guanines interact through Hoogsteen hydrogen bonds forming a tetrad which is stabilized by metallic ...
Súarez López, Lucía (Fecha de defensa: 2013-07-05)
Durante la división celular, el ADN debe estructurarse en cromosomas para asegurar un correcto reparto de la información genética a las dos células hijas. El complejo condensina, junto con el motor ...
Martínez Redondo, Paloma (Fecha de defensa: 2014-06-25)
The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded ...
Benito Mauricio, Adrián (Fecha de defensa: 2014-02-21)
The present doctoral thesis is focused on the metabolic adaptations induced by oncogene activation as well as the potential role of the metabolic network as antitumor therapy. Over the last years, it ...
Segura Bayona, Sandra (Fecha de defensa: 2018-06-22)
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication ...
Raimondi, Giulia (Fecha de defensa: 2020-06-08)
The general goal of this thesis has been to progress oncolytic adenovirus therapy for PDAC, by the incorporation of novel preclinical models to test for patient-specific responses and the generation of ...
Terribas Pérez, Ernest (Fecha de defensa: 2016-01-20)
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 ...
Rodilla Martín, Ananda Marina (Fecha de defensa: 2018-04-10)
Oral and lung cancer are included in the most prevalent respiratory diseases, being the latter one of the main causes of mortality worldwide. Despite new advances in diagnosis and clinical care, success ...