Martín Liberal, Juan Jesús (Date of defense: 2016-11-07)
Sarcomas are a group of malignancies characterized by their bad prognosis and the absence of effective treatments. Median survival of advanced sarcoma patients is only one year in spite of treatment. ...
Nadal Sanmartin, Cristina (Date of defense: 2007-07-24)
1 INTRODUCCIÓN<br/><br/>El cáncer colorrectal (CCR) es la tercera causa de diagnóstico de cáncer en todo el mundo. El 11-27% de pacientes se diagnostican en estadio avanzado o metastático. De los ...
Rodríguez Mías, Ricard Aleix (Date of defense: 2006-10-05)
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present ...
Zamudio Vázquez, Rubí (Date of defense: 2014-02-14)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit ...
Sostoa Pomés, Jana de (Date of defense: 2019-05-31)
Oncolytic virus (OV)-based therapies have an emerging role in the treatment of solid tumors, involving both direct cell lysis and immunogenic cell death. Nonetheless, tumor- associated stroma limits the ...
Fajardo Calderón, Carlos Alberto (Date of defense: 2017-05-19)
Oncolytic adenoviruses that selectively replicate in cancer cells while sparing normal tissue have gained considerable attention as novel anticancer drugs. However, clinical trials with these viruses ...
Félez Sánchez-Ocaña, Marta (Date of defense: 2017-06-29)
Papillomaviruses (PVs) are a numerous family of small dsDNA viruses infecting virtually all mammals. PVs cause infections without triggering a strong immune response, and natural infection provides ...
Albert Colomer, Nerea (Date of defense: 2021-01-18)
Tumor-stroma crosstalk is essential for PDAC formation. Therefore, the stroma, and specifically the carcinoma-associated fibroblasts (CAFs), are the target of therapeutic alternatives to treat highly ...
Soucek, Richard (Date of defense: 2014-01-28)
The study deals with the synthesis and biological activity of 4 different antitumours: Tetrahydro-[1,4]-dioxanisoquinolines, combretastatin A-4, dioxancarbazoles and resveratrol analogues. This study ...
Obiol Pardo, Cristian (Date of defense: 2008-10-13)
Cancer is the second disease leading cause of death in industrialized countries. Although early detection and more efficient drugs are responsible of the reduction of mortality, several cancers still ...