Rodilla Martín, Ananda Marina (Date of defense: 2018-04-10)
Oral and lung cancer are included in the most prevalent respiratory diseases, being the latter one of the main causes of mortality worldwide. Despite new advances in diagnosis and clinical care, success ...
Fernández Alfara, Marcos (Date of defense: 2022-04-07)
Translation of mRNAs into proteins is a highly regulated step of gene expression. In cancer, post-transcriptional and translational control have a critical effect on transformation, controlling ...
Acevedo Lipes, Andrea Milena (Date of defense: 2021-03-09)
Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of ...
Franco Valls, Héctor (Date of defense: 2022-05-26)
SNAIL1 is a transcription factor with roles in repression of epithelial genes and enhancement of mesenchymal genes. As such, it plays a key role in Epithelial-to-mesenchymal transition and in fibroblast ...
Cortés Hinojosa, Marlies (Date of defense: 2017-05-26)
ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages ...
Martorell Aleman, Òscar (Date of defense: 2014-03-25)
During last decades many researchers have tried to elucidate the different causes of tumour initiation and progression. For this purpose, multiple animal models have been developed to understand the ...
Moreno Cabrera, José Marcos (Date of defense: 2021-06-17)
This PhD thesis has been carried out with the aim of improving, from a bioinformatic-based approach, the genetic diagnostics of hereditary cancer. More specifically, the aims were: 1. To perform a ...
Sallaberry Pinto, Júlia (Date of defense: 2019-03-22)
Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and ...
Aubets Gil, Eva (Date of defense: 2021-09-19)
This work is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as a gene silencing tool, and on the search of alternative methods for their delivery, including viral and non-viral ...
Rodríguez Gallego, Laura (Date of defense: 2015-03-13)
The work presented in this thesis is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as gene silencing tools. PPRHs are double-stranded DNA molecules formed by tvvo anti parallel ...