Calatayud Robert, Sara (Date of defense: 2021-12-20)
Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During ...
Torres Núñez, Eva (Date of defense: 2014-02-21)
The Extracellular Matrix (ECM) is a complex network secreted by cells that serves as a structural element in tissues and also influences their development and physiology. More specifically, the extracellular ...
Sfriso, Pedro (Date of defense: 2016-03-18)
Sequence, structure and dynamics are an indivisible tandem to understand protein function. Luckily, evolution imposed a hierarchical rational between that facilitates the analysis: dynamics are encoded ...
Esquerdo Barragan, Mariona (Date of defense: 2017-05-26)
Protein post-translational modifications are regulatory mechanisms that cells use in response to intra- and extracellular signals. These signals modulate a panoply of conjugating enzymes that modify ...
Frager, Petra (Date of defense: 2022-10-28)
[eng] Decreased physical activity and increased consumption of energy-rich food are hallmark lifestyle modifications that developed and amplified over the course of only a few decades. These changes in ...
Montaño Sierra, José Javier (Date of defense: 2022-11-02)
[spa] Las células asesinas naturales T invariantes (iNKT, de las siglas en inglés de invariant natural killer T cells), también células asesinas invariantes de tipo I, son una población inmunitaria de ...
Ramiro-Pareta, Marina (Date of defense: 2022-03-31)
The pleiotropic WT1 transcription factor (WT1) was first discovered in renal tumours. It contains four zinc-finger motifs at the C-terminus which are important for DNA binding to activate gene expression ...
Plana-Bonamaisó, Anna Maria (Date of defense: 2020-05-15)
The main aim of this work was to characterize the molecular mechanisms that underlie the physiopathology of LCA12 and RP10, that are inherited retinal dystrophies caused by alterations in guanine ...
Bagiński, Błażej Mikołaj (Date of defense: 2022-12-15)
[eng] Tumour progression largely depends on the signalling networks that direct cell viability, growth and dissemination (metastasis). Transforming growth factor beta (TGF-β) and Bone Morphogenetic ...
Ruiz Serra, Victoria Isabel (Date of defense: 2023-11-08)
[eng] Proteins are fundamental building blocks of life, and understanding their structure and function is crucial for many fields of science, from drug discovery to bioengineering. Traditional experimental ...