Oller Salvia, Benjamí (Date of defense: 2015-05-18)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural ...
Gordo Villoslada, Susana (Date of defense: 2008-06-30)
Protein-protein interactions are essential in biological processes and thus, they have become very promising therapeutic targets. Nevertheless, the artificial modulation of protein complexes remains a ...
Le Roux, Anabel-Lise (Date of defense: 2015-11-18)
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src ...
Serra Vidal, Bernat (Date of defense: 2014-05-27)
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β ...
Vila Farrés, Xavier (Date of defense: 2014-11-14)
Nowadays in the world there is a very big problem associated with two factors related to each other. The first factor is the increase in the resistant of certain bacteria, especially the bacteria from ...
Guixer, Bernat (Date of defense: 2014-03-31)
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct ...
Ciudad Fernández, Sonia (Date of defense: 2016-11-08)
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition. Peptides present several advantages when compared with small ...
Arranz Gibert, Pol (Date of defense: 2017-01-12)
The work of this thesis is based on research on peptides able to cross the blood-brain barrier and their use as tools to enable the delivery of drugs into the brain. The blood-brain barrier (BBB) is ...