Silva, Rui Gonçalo Teixeira da (Date of defense: 2022-09-16)
Steatotic livers are considerably more prone to IRI, in which turn, it is known to impair mitochondrial function. Our working hypothesis lies on the fact that impaired mitochondrial function and reduced ...
Ninfali, Chiara (Date of defense: 2019-12-13)
Muscle atrophy, which is characterized by excessive protein catabolism, is one of the major adaptive processes that occur in several physiopathological and clinical conditions, to counteract stressing ...
González Burón, Helena (Date of defense: 2014-03-19)
The human Tousled-like kinases 1 and 2 (TLKs) are predicted serine/threonine kinases that show maximal activity in S phase and are transiently inhibited by the DNA damage response (DDR). Both TLKs ...
Castillo Figueroa, Ana Lucía (Date of defense: 2017-04-24)
A number of recent studies in animals and humans have linked energy regulation and the circadian clock at the molecular, physiological and behavioral levels, concluding that disruption of clock genes ...
Creus i Cuadros, Anna (Date of defense: 2018-02-27)
The World Health Organization (WHO) 1 says that CVDs are number one cause of death globally. An estimated 17.7 million people died from CVDs in 2015, representing 31% of all global deaths. Over three ...
Hessheimer, Amelia Judith (Date of defense: 2011-04-13)
The hypothesis of this doctoral thesis is two-fold: 1. Excessive portal vein flow is present immediately after portal reperfusion in the recipient and is the instigating factors in a series of events ...
Sánchez Tilló, Ester (Date of defense: 2006-05-18)
Macrophages are key regulators of immune system connecting innate and specific immune responses. Macrophages proliferate in presence of their growth factor, M-CSF. The addition of bacterial lipopolysacharide, ...
Simões, Inês Tadeu dos Anjos (Date of defense: 2017-09-14)
Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- ...
Balaguer Núñez, María Dolores (Date of defense: 2006-01-16)
The aim of this thesis, devised as a collaboration between Spain and China, is the characterization of the open clusters NGC 1807, NGC 1817, NGC 2548 and NGC 2682, as well as the analysis of the results ...
Guignard, Guillaume Michel Pablo (Date of defense: 2016-06-23)
1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive ...