Aledavood, Elnaz (Date of defense: 2021-10-01)
This doctoral thesis is focused on disclosing molecular factors that regulate the functional mechanism of key targets in i) metabolic disorders, such as diabetes and obesity, and ii) tuberculosis (TB). ...
Pascual Gilabert, Marta (Date of defense: 2022-11-04)
[eng] Myotonic dystrophy type 1 (DM1), one of the more complex diseases already known, is the most common and multisystemic rare neuromuscular disease among adults, without cure and limited pharmacological ...
Escobedo Pascual, Albert (Date of defense: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Villamor Payà, Marina (Date of defense: 2021-07-08)
The Tousled like kinases 1 and 2 (TLK1 and TLK2) are evolutionarily conserved Ser/Thr kinases that are required for genome stability and normal development in numerous organisms. Both kinases contribute ...
Liu, Changxin (Date of defense: 2020-10-29)
The main topic of this Thesis is to investigate the contribution of polyamines to defense in Arabidopsis thaliana and the requirement of callose deposition for full expression of effector-triggered ...
Domenech Pena, Arnau (Date of defense: 2013-12-03)
It is estimated that within a few years chronic obstructive pulmonary disease (COPD) will be the third leading cause of death worldwide. The morbidity and mortality associated with COPD are due, in part ...
Cánovas Bilbao, Begoña (Date of defense: 2017-07-20)
In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival ...
Ramírez Ruiz, Blanca (Date of defense: 2006-07-03)
Cognitive impairment of different degrees and hallucinations are common complications of chronic Parkinson's disease (PD). The pathogenesis, pathophysiology, and relationship between cognitive deficits ...
Román González, Lidia (Date of defense: 2014-01-31)
Within the hematopoietic system, all mature blood cells are generated. Every differentiation step is characterized by the activation of a new, lineage specific, genetic program and the extinction of the ...
Holtschlag, Claudia (Date of defense: 2014-04-24)
In this dissertation, I contribute to the literature that addresses why some people are more successful in their careers than others. Within this stream of research, scholars have increasingly examined ...