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Showing 10 out of a total of 24 results for community: Universitat de Barcelona. (2.235 seconds)
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(Date of defense: 09-12-2013)Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational modulation. ...
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(Date of defense: 14-02-2014)Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
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(Date of defense: 15-02-2013)Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...
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(Date of defense: 05-12-2013)Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...
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(Date of defense: 15-05-2015)The known as "difficult peptides", as well as those sequences that aggregate in solution, are some of those molecules with high applicability as nanomaterials or even in medicine field. This thesis has addressed to overcome ...
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(Date of defense: 25-11-2013)The present doctoral thesis has been devoted to the development of a new synthetic strategy to obtain a new member of the thiopeptide, or thiazolyl peptide, family of antibiotics. This new member, baringolin, was isolated ...
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(Date of defense: 21-03-2014)Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...
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(Date of defense: 21-07-2014)El estudio de los gamma-péptidos miméticos basados en cis-gamma-amino-L-prolina con capacidad de atravesar la membrana celular en diferentes organismos, constituye una temática de gran interés en el área de biomedicina ...
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(Date of defense: 23-05-2014)CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic conditions such as ...
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(Date of defense: 18-07-2014)Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...
