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Showing 10 out of a total of 23 results for community: Universitat de Barcelona. (1.255 seconds)

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Backbone N-modified peptides: beyond N-methylation

Fernández-Llamazares Onrubia, Ana Iris (Date of defense: 09-12-2013)
Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational modulation. ...
Synthesis, Biological Evaluation and Insights into the Mode of Action of Quinoxaline Containing Peptides

Zamudio Vázquez, Rubí (Date of defense: 14-02-2014)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
Synthesis, structural elucidation and biological evaluation of Pipecolidepsin A and Phakellistatin 19

Pelay Gimeno, Marta (Date of defense: 15-02-2013)
Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...
Synthesis and versatile applications of oligoethylene glycol dendrons using click chemistry

Fransen, Peter (Date of defense: 05-12-2013)
Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...
Development of New Tools for the Synthesis of "Difficult Peptides"

Paradís Bas, Marta (Date of defense: 15-05-2015)
The known as "difficult peptides", as well as those sequences that aggregate in solution, are some of those molecules with high applicability as nanomaterials or even in medicine field. This thesis has addressed to overcome ...
Thiopeptides: Synthesis and Structure-Activity Relationship Studies

Just Baringo, Xavier (Date of defense: 25-11-2013)
The present doctoral thesis has been devoted to the development of a new synthetic strategy to obtain a new member of the thiopeptide, or thiazolyl peptide, family of antibiotics. This new member, baringolin, was isolated ...
Novel Disulfide Formation Strategies in Peptide Synthesis

Postma, Tobias Maria (Date of defense: 21-03-2014)
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...
Péptidos miméticos con capacidad de atravesar barreras biológicas

Pulido Villamil, Ximena Carolina (Date of defense: 21-07-2014)
El estudio de los gamma-péptidos miméticos basados en cis-gamma-amino-L-prolina con capacidad de atravesar la membrana celular en diferentes organismos, constituye una temática de gran interés en el área de biomedicina ...
Small molecules for modulating biological targets

Miret Casals, Laia (Date of defense: 23-05-2014)
CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic conditions such as ...
Marine Natural Products. Synthesis and structure determination

Lorente Crivillé, Adriana (Date of defense: 18-07-2014)
Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...