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Mostrant 10 d'un total de 23 resultats per la comunitat: Universitat de Barcelona. (3.665 segons)

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Noves estructures basades en aminoàcids trifuncionals: foldàmers i quimioteques basades en derivats de prolina

Farrera Sinfreu, Josep Maria
Les molècules ramificades poden jugar un paper clau en la síntesi en fase sòlida de compostos amb una elevada complexitat estructural. En aquest sentit i concretament en la síntesi de pèptids i peptidomimètics, els aminoàcids ...
New Orthogonal Strategies for Peptide Synthesis

Góngora Benítez, Miriam (Data de defensa: 08-02-2013)
Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during peptide elongation, and ...
Productes naturals com a font de nous fàrmacs: Síntesi en fase sòlida de depsipèptids ciclics i aïllament d'agents antitumorals d'esponges marines

Bayó Puxan, Núria
Els productes naturals són de gran importància en els sistemes de prevenció i de cura de les dolences i malalties de l'ésser humà. Així, un 50% dels fàrmacs actuals estan basats en productes naturals i un 80% de la població ...
New Protecting Groups for the Synthesis of Complex Peptides

Isidro Llobet, Albert
The increasing importance of peptides as drugs creates the necessity of new methodologies for the synthesis of complex peptides. This PhD thesis has been focused on the development of new protecting groups (including new ...
Mayotlide: synthetic approaches and structural elucidation

Herraiz Cobo, Jesús (Data de defensa: 13-07-2017)
Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy revealed the presence ...
Synthesis, Biological Evaluation and Insights into the Mode of Action of Quinoxaline Containing Peptides

Zamudio Vázquez, Rubí (Data de defensa: 14-02-2014)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
Synthesis, structural elucidation and biological evaluation of Pipecolidepsin A and Phakellistatin 19

Pelay Gimeno, Marta (Data de defensa: 15-02-2013)
Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...
Péptidos miméticos con capacidad de atravesar barreras biológicas

Pulido Villamil, Ximena Carolina (Data de defensa: 21-07-2014)
El estudio de los gamma-péptidos miméticos basados en cis-gamma-amino-L-prolina con capacidad de atravesar la membrana celular en diferentes organismos, constituye una temática de gran interés en el área de biomedicina ...
Small molecules for modulating biological targets

Miret Casals, Laia (Data de defensa: 23-05-2014)
CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic conditions such as ...
Marine Natural Products. Synthesis and structure determination

Lorente Crivillé, Adriana (Data de defensa: 18-07-2014)
Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...