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Showing 10 out of a total of 23 results for community: Universitat de Barcelona. (1.152 seconds)
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(Date of defense: 02-05-2013)The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or ...
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(Date of defense: 18-05-2015)Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
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(Date of defense: 18-11-2015)c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...
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Actualment, les proteïnes implicades en la biosíntesi i la degradació dels neuropéptidos estan cobrant un gran interès com a possibles noves dianes terapèutiques ja que determinen els nivells de neuropèptid actiu i en ...
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(Date of defense: 06-06-2014)Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study in four proteases: ...
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(Date of defense: 27-05-2014)Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...
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En la presente tesis doctoral se ha desarrollado una nueva estrategia de química combinatoria para la modificación de la hélice alfa C-terminal del dominio B de la proteína A de Staphylococcus Aureus, extensible a la ...
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(Date of defense: 15-04-2013)In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
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El comportament reproductor en moltes espècies d'insectes implica l'alliberament per part de la femella d'una sèrie de compostos químics volàtils, anomenats feromones, els quals són detectats de forma molt específica, a ...
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(Date of defense: 04-07-2016)During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...
