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Showing 10 out of a total of 57 results for community: Universitat de Barcelona. (0.531 seconds)

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SOX11 transcription factor functional analysis in aggressive MCL

Vegliante, Maria Carmela (Date of defense: 26-09-2013)
Mantle cell lymphoma (MCL) is an aggressive subtype of non-Hodgkin lymphomas associated with poor prognosis and frequent relapses. Recently, the neuronal transcription factor SOX11 has been identified as a very specific ...
The epigenetic regulation of cell cycle and chromatin dynamic by sirtuins

Martínez Redondo, Paloma (Date of defense: 25-06-2014)
The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded in the DNA. The ...
Mantle cell lymphoma pathogenesis: another turn of the screw to cyclin D1 overexpression

Albero Gallego, Robert (Date of defense: 21-07-2017)
Mantle cell lymphoma (MCL) is an aggressive lymphoid neoplasm derived from mature B cells characterized by the presence of the t(11;14)(q13;q32) translocation that leads to the overexpression of Cyclin D1. Cyclin D1 plays ...
Role of ZEB1 in macrophages during homeostasis, inflammation and cancer

Cortés Hinojosa, Marlies (Date of defense: 26-05-2017)
ZEB1 is a transcription factor whose expression in cancer cells promotes tumor initiation and progression. In this study, we for the first time characterized Zeb1 and study its function in macrophages under either homeostasis ...
Innovative targeted therapies for chemorefractory B-cell non-Hodgkin lymphomas

Esteve Arenys, Anna (Date of defense: 22-12-2017)
Lymphomas are a heterogeneous group of tumors characterized by the proliferation of lymphocytes predominantly in lymphoid structures but also in extranodal tissues. More than 90% of patients are afflicted by lymphomas ...
Neural Stem Cell Factors as Important Players in Glioblastoma Pathogenesis

Moreno Monasterio, Marta (Date of defense: 18-02-2015)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, which might be ...
Susceptibilidad a Melanoma: nuevos aspectos clínico-patológicos, desarrollo de herramientas y modelos de estudio y evaluación de medidas preventivas

Aguilera Peiró, Paula (Date of defense: 23-09-2015)
El trabajo contenido en esta Tesis Doctoral ha ido encaminado a mejorar el conocimiento del Melanoma Familiar con el fin de mejorar su prevención y tratamiento. En el primero de los trabajos publicados se han descrito y ...
A network biology approach to breast and colorectal cancers

Arroyo Sánchez, Rodrigo (Date of defense: 20-06-2014)
Network and systems biology disciplines could revolutionize the study of complex diseases by taking proteins back to their context, considering a much broader perspective of their environment without losing the molecular ...
Inhibidors de cinases com a estratègia terapèutica en neoplàsies limfoides

Rosich Moya, Laia (Date of defense: 05-06-2014)
La via de supervivència PI3K/AKT/mTOR es troba constitutivament activada en molts tumors, fet que ha afavorit el desenvolupament de nombrosos inhibidors al considerar-se una possible opció terapèutica. Tant el MCL com la ...
Description and Pre-clinical Validation of Dynamic Molecular Determinants of Sensitivity to Aromatase Inhibitors in Breast Cancer / Descripción y Validación Pre-Clínica de Marcadores Moleculares Dinámicos de Sensibilidad a Inhibidores de la Aromatasa en Cáncer de Mama.

Urruticoechea Ribate, Ander
DE LA TESIS:El cáncer primario de mama es un problema de salud de gran magnitud con una incidencia estimada de 1 de cada 10 mujeres. De entre los tratamientos sistémicos, el tratamiento hormonal cuenta con un papel más ...