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Showing 10 out of a total of 23 results for community: Universitat de Barcelona. (0.378 seconds)

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NMR in drug discovery. From screening to structure-based design of antitumoral agents

Rodríguez Mías, Ricard Aleix
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present thesis we propose ...
Synthesis of biaryl bicyclic peptides for recognition of protein surfaces

Garcia Pindado, Júlia (Date of defense: 12-05-2017)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Cyclic peptides and small proteins in molecular recognition

Ciudad Fernández, Sonia (Date of defense: 08-11-2016)
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition. Peptides present several advantages when compared with small molecules and biologics: ...
Disseny, síntesi i estudi de lligands peptídics capaços de reconèixer la superfície de la P53

Martinell Pedemonte, Marc
En la majoria de processos cel·lulars, hi ha multitud de proteïnes que interaccionen entre sí, essent aquests contactes proteïna-proteïna, fonamentals per al correcte funcionament de cadascun d'aquests processos. Aquests ...
Diseño, síntesis y evaluación de inhibidores de la proteína beta-amiloide. Desarrollo de un modelo de fibrilogénesis

Cruz Gatell, Montse
La hipótesis amiloide de la enfermedad de Alzheimer fue la base, hace algunos años, para el desarrollo de una línea de investigación cuyo objetivo principal es la obtención de pequeñas moléculas peptídicas capaces de ...
Use of calix[4]arenes to recover the self-assembly ability of mutated p53 tetramerization domains

Gordo Villoslada, Susana
Protein-protein interactions are essential in biological processes and thus, they have become very promising therapeutic targets. Nevertheless, the artificial modulation of protein complexes remains a challenge. Since most ...
Diseño, síntesis y estructura de dominios helicoidales. Influencia de la introducción de aminoácidos D.

Granados Ramírez, Carmen Giovana
1) "Diseño, síntesis y caracterización de inhibidores de la fusión de VIH-1 análogos del péptido C34 de gp41 con D aminoácido"En el proceso de fusión del virus del VIH-1 a la célula diana intervienen las proteínas de la ...
Design, synthesis and biophysical evaluation of peptides targeting pharmacologically relevant proteins

Guardiola Bagán, Salvador (Date of defense: 15-09-2017)
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed to provide effective ...
Blood-Brain Barrier Shuttles: From Design to Application

Arranz Gibert, Pol (Date of defense: 12-01-2017)
The work of this thesis is based on research on peptides able to cross the blood-brain barrier and their use as tools to enable the delivery of drugs into the brain. The blood-brain barrier (BBB) is a permeable but ...
Chemically synthesized peptide libraries as a new source of BBB-shuttles. Use of Mass Spectrometry for peptide identification and quantification

Guixer, Bernat (Date of defense: 31-03-2014)
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct function of this organ. ...