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Role of Methylation in Modulating MAPK Signaling. Implications in Melanoma. Papel de la metilación como modulador de la señalización en MAPK. Implicaciones en melanoma.

Andreu Pérez, Pedro Antonio (Date of defense: 2012-03-12)

1. General Overview MTAP is a key enzyme in the methionine salvage pathway and controls the levels of methylthioadenosine (MTA). Lost of MTAP, which is frequent in melanoma, results in higher intra and ...

Nucleosome positioning on chromatin using bioinformatics techniques = Posicionament de nucleosomes en cromatina emprant tècniques bioinformàtiques

Flores Guri, Oscar (Date of defense: 2014-06-10)

This thesis presents a broad study of the chromatin structure and function with special focus in the nucleosome organization. More specifically, it includes three different but complementary perspectives: ...

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