Ara mostrant els elements 134-143 de 143
Fransen, Peter (Data de defensa: 2013-12-05)
Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...
Garcia Pindado, Júlia (Data de defensa: 2017-05-12)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...
Martín-Gago, Pablo (Data de defensa: 2013-10-11)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...
Pelay Gimeno, Marta (Data de defensa: 2013-02-15)
Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...
Heras, Carlos, 1986- (Data de defensa: 2016-01-18)
Se han sintetizado una nueva familia de moléculas, puramente orgánicas y con número par de electrones, que presentan propiedades paramagnéticas. El trabajo de esta tesis ha consistido en conocer el fundamento por el cual ...
Vilaprinyó Pascual, Sílvia (Data de defensa: 2015-07-27)
Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant processing of Aß ...
Doran, Seán (Data de defensa: 2012-12-14)
This doctoral thesis was focused on the design and synthesis of novel chiral ligands for application in asymmetric catalysis. One of the best examples of asymmetric catalysis is the asymmetric hydrogenation reaction for ...
Just Baringo, Xavier (Data de defensa: 2013-11-25)
The present doctoral thesis has been devoted to the development of a new synthetic strategy to obtain a new member of the thiopeptide, or thiazolyl peptide, family of antibiotics. This new member, baringolin, was isolated ...
Broto Avilés, Marta (Data de defensa: 2017-09-18)
La medicina personalitzada esta prenent rellevància últimament. Aquesta es basa en la monitorització simultània de diferents biomarcadors, els biomarcadors poden ser molècules de diferent naturalesa química. Aquest fet fa ...
Gordo Villoslada, Susana (Data de defensa: 2008-06-30)
Protein-protein interactions are essential in biological processes and thus, they have become very promising therapeutic targets. Nevertheless, the artificial modulation of protein complexes remains a challenge. Since most ...