Ara mostrant els elements 54-73 de 143
Messeguer Escriche, Joaquim (Data de defensa: 2007-07-17)
La recerca en el camp del desenvolupament de fàrmacs peptídics i peptidomimètics ha experimentat una evolució important durant els darrers anys. Els fàrmacs peptídics sovint presenten baixa disponibilitat oral, una vida ...
Viladoms Claverol, Júlia (Data de defensa: 2008-11-12)
Els àcids nucleics poden existir a la natura en una varietat de formes estructurals potencialment rellevants per al funcionament i la regulació dels gens. Aquesta tesi doctoral versa sobre una estructura no canònica del ...
Oller Salvia, Benjamí (Data de defensa: 2015-05-18)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural cell to supply it ...
Díaz Perlas, Cristina (Data de defensa: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) and as new BBB-shuttles, ...
Canal Barcala, Ivan (Data de defensa: 2016-01-22)
Se ha estudiado espectroscópicamente (UV-Vis, Raman, RMN) los equilibrios tautoméricos del ácido 2-(4'-hidroxifenilazo)benzoico (HABA) y el ácido 2-(4'-hidroxi-3',5'- dimetilfenilazo)benzoico. Estos equilibrios están ...
Heras i Cisa, F. Xavier de las (Francesc Xavier) (Data de defensa: 1989-02-27)
La memòria té dos apartats diferenciats. Al primer es caracteritzen des del punt de vista estructural bio-marcadors (o fòssils moleculars) com ara hidrocarburs alifàtics, alicílics i aromàtics, compostos oxigenats (alcohols, ...
Defaus Fornaguera, Sira (Data de defensa: 2014-06-20)
Glycosylation is a posttranslational modification affecting the fast majority of cellular surfaces through glycolipids and glycoproteins. It has been estimated that over 80% of all proteins are glycosylated and that the ...
Escudero Rodríguez, Carlos (Data de defensa: 2007-12-18)
Esta tesis doctoral tiene como objetivo general el estudio de los procesos de agregación de porfirinas sulfonadas amfifílicas. <br/><br/>En el primer capítulo se presentan los trabajos dirigidos a la obtención de porfirinas ...
Montagut Cañete, Enrique José (Data de defensa: 2021-02-04)
The final goal of the thesis was to improve the diagnostic of infections caused by P. aeruginosa and S. aureus through a better understanding of the bacterial communication process known as Quorum Sensing (QS) and its ...
López Ibáñez, Alba (Data de defensa: 2013-11-14)
Para frenar la creciente resistencia del Plasmodium, el parásito causante de la malaria, se necesitan nuevos fármacos con modos de acción diferentes a los de los fármacos actualmente existentes. Esta tesis se centra en ...
Khaizourane, Héléa (Data de defensa: 2016-03-11)
The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated [2+2+1] ...
Ramos Tomillero, Iván (Data de defensa: 2016-07-15)
Cancer is a heterogeneous disease that represents one of the principal causes of mortality in developed countries. Due to the social and economic implications of this pathology, tremendous efforts have been making over the ...
Solà i Oller, Jordi (Data de defensa: 2006-12-20)
La reacció de Pauson-Khand (PK) és formalment una cicloaddició 2+1+1 entre un alquè, un alquí i una molècula de monòxid de carboni per donar lloc a una ciclopentenona. Aquesta reacció està mediada per una espècie de cobalt ...
Terrazas Martínez, Montserrat (Data de defensa: 2006-07-13)
En la present Tesi s'han intentat desenvolupar noves metodologies que permetin modificar les nucleobases puríniques dels nucleòsids amb dues intencions clarament diferenciades: d'una banda, el seu marcatge amb 15N, per tal ...
Lorente Crivillé, Adriana (Data de defensa: 2014-07-18)
Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...
Herraiz Cobo, Jesús (Data de defensa: 2017-07-13)
Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy revealed the presence ...
Alvira Torre, Margarita (Data de defensa: 2010-10-25)
Oligonucleotides are short fragments of DNA (10-100nt) which are of great interest because their applications in molecular biology, biomedicine and nanotechnology. As a result of their ability to base pairing, oligonucleotides ...
Dyachenko, Andrey (Data de defensa: 2013-04-15)
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
Rocas Alonso, Pau (Data de defensa: 2016-02-25)
This thesis, entitled "Multifunctional Self-stratified Polyurethane-Polyurea Nanosystems for Smart Drug Delivery" is structured as a compendium of publications, being organized around a methodological synthetic patent and ...
Colom Sanmartí, Glòria (Data de defensa: 2016-01-28)
In the course of this thesis, the optimal epitopes for the subsequent polyclonal rabbit antibody production for cTnI and NT-proBNP have been studied and chosen. cTnI and NT-proBNP are the most relevant cardio-specific ...