Mostrando ítems 66-85 de 144
Ramos Tomillero, Iván (Fecha de defensa: 2016-07-15)
Cancer is a heterogeneous disease that represents one of the principal causes of mortality in developed countries. Due to the social and economic implications of this pathology, tremendous efforts have been making over the ...
Solà i Oller, Jordi (Fecha de defensa: 2006-12-20)
La reacció de Pauson-Khand (PK) és formalment una cicloaddició 2+1+1 entre un alquè, un alquí i una molècula de monòxid de carboni per donar lloc a una ciclopentenona. Aquesta reacció està mediada per una espècie de cobalt ...
Terrazas Martínez, Montserrat (Fecha de defensa: 2006-07-13)
En la present Tesi s'han intentat desenvolupar noves metodologies que permetin modificar les nucleobases puríniques dels nucleòsids amb dues intencions clarament diferenciades: d'una banda, el seu marcatge amb 15N, per tal ...
Lorente Crivillé, Adriana (Fecha de defensa: 2014-07-18)
Natural products from terrestrial plants and microorganisms have long been a traditional source of drugs. For centuries humans have been looking on their environment for medicines to treat illnesses. But unlike terrestrial ...
Herraiz Cobo, Jesús (Fecha de defensa: 2017-07-13)
Mayotlide is a marine peptide isolated by PharmaMar S.A. from Spongia sp.. The sequence of the aminoacids were achieved by MS-MS spectrometry, where two of them were tryptophans. The NMR spectroscopy revealed the presence ...
Alvira Torre, Margarita (Fecha de defensa: 2010-10-25)
Oligonucleotides are short fragments of DNA (10-100nt) which are of great interest because their applications in molecular biology, biomedicine and nanotechnology. As a result of their ability to base pairing, oligonucleotides ...
Dyachenko, Andrey (Fecha de defensa: 2013-04-15)
In the present thesis we have explored different factors that impede accurate quantitative description of non-covalent protein-protein and protein-ligand interactions and design of new potent and specific binders from the ...
Rocas Alonso, Pau (Fecha de defensa: 2016-02-25)
This thesis, entitled "Multifunctional Self-stratified Polyurethane-Polyurea Nanosystems for Smart Drug Delivery" is structured as a compendium of publications, being organized around a methodological synthetic patent and ...
Colom Sanmartí, Glòria (Fecha de defensa: 2016-01-28)
In the course of this thesis, the optimal epitopes for the subsequent polyclonal rabbit antibody production for cTnI and NT-proBNP have been studied and chosen. cTnI and NT-proBNP are the most relevant cardio-specific ...
Le Roux, Anabel-Lise (Fecha de defensa: 2015-11-18)
c-Src is the leading member of the Src family of non-receptor tyrosine kinases, which are involved in many signaling pathways. Its deregulation affects cell migration, proliferation and survival. c-Src is composed of the ...
Góngora Benítez, Miriam (Fecha de defensa: 2013-02-08)
Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during peptide elongation, and ...
Isidro Llobet, Albert (Fecha de defensa: 2008-05-13)
The increasing importance of peptides as drugs creates the necessity of new methodologies for the synthesis of complex peptides. This PhD thesis has been focused on the development of new protecting groups (including new ...
Garcia Garcia, Josep (Fecha de defensa: 2016-07-04)
During the past years working in Ernest Giralt’s group, I’ve been involved in three different subprojects that constitute one of the three chapter of my thesis and have the same common link: the use of peptides combined ...
Rodríguez Mías, Ricard Aleix (Fecha de defensa: 2006-10-05)
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present thesis we propose ...
Trapero Puig, Ana (Fecha de defensa: 2011-03-21)
Els malalts de Gaucher manquen de l’activitat normal de l’enzim lisosomal Glucocerebrosidasa (GCase), una β–glucosidasa que hidrolitza l’enllaç glicosídic entre la glucosa i la ceramida, i són incapaços de metabolitzar la ...
Subirós Funosas, Ramon (Fecha de defensa: 2011-07-21)
Els pèptids són biopolímers naturals amb una importància cabdal en el cos humà, actuant com a neurotransmissors, endorfines o hormones. Recentment, s’han descobert propietats molt interessants de pèptids amb aplicacions ...
Adrián Izquierdo, Javier (Fecha de defensa: 2012-09-28)
The indiscriminate and/or improper use of veterinary drugs is the cause of potential adverse health effects due to the risk of entering into the food chain and the appearance of residues in food products of animal origin. ...
Rodríguez Ramírez, Aleix (Fecha de defensa: 2014-10-31)
En aquesta Tesi, s’ha estudiat l’aplicació dels al•lens en dues metodologies: el procés tàndem d’hidroboració d’al•lens i posterior addició a aldehids i la inserció d’al•lens a benzilamines i feniletilamines catalitzada ...
Ortiz Gil, Jordi (Fecha de defensa: 2006-10-31)
En la primera part d'aquesta tesi s'ha portat a terme un ampli estudi de la reacció d'addició d'acetilurs de zinc derivats d'1-alquin-3-ols quirals enriquits enantiomèricament per a obtenir 2-alquin-1,4-diols, tot adaptant ...
Pastells Díez, Carme (Fecha de defensa: 2016-01-19)
Aquesta tesi s'ha focalitzat en el desenvolupament de noves eines immunoquímiques per al diagnòstic de malalties infeccioses amb l'objectiu d'incrementar l'eficiència dels actuals mètodes de diagnòstic. Concretament, aquesta ...