Browsing Departament de Química Orgànica by Title

Now showing items 134-143 of 143

Synthesis and versatile applications of oligoethylene glycol dendrons using click chemistry

Fransen, Peter (Date of defense: 2013-12-05)

Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...

Synthesis of biaryl bicyclic peptides for recognition of protein surfaces

Garcia Pindado, Júlia (Date of defense: 2017-05-12)

The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl bridge. The metholodogy ...

Synthesis of Highly Structured and Receptor-Selective Tetradecapeptidic Analogs of Somatostatin: Fine-tuning the non-covalent interactions among their aromatic residues

Martín-Gago, Pablo (Date of defense: 2013-10-11)

Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...

Synthesis, structural elucidation and biological evaluation of Pipecolidepsin A and Phakellistatin 19

Pelay Gimeno, Marta (Date of defense: 2013-02-15)

Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...

Tautomería de valencia en moléculas con número par de electrones: transición térmica al estado electrónico triplete inducida por un cambio conformacional. Nuevos materiales con comportamientos ferromagnéticos

Heras, Carlos, 1986- (Date of defense: 2016-01-18)

Se han sintetizado una nueva familia de moléculas, puramente orgánicas y con número par de electrones, que presentan propiedades paramagnéticas. El trabajo de esta tesis ha consistido en conocer el fundamento por el cual ...