Castellanos Ortega, Sonia (Date of defense: 2010-05-07)
Molecular electronics is an emergent area of the new technologies related to the use of organic and biological materials in optoelectronic and electronic devices. Among the materials used in electronic ...
Tapia Pérez, Lucía (Date of defense: 2021-10-01)
This PhD thesis lays on the field of supramolecular chemistry. In this field, there is a huge interest in the development of cage-like compounds able to bind biologically relevant molecules inside their ...
Blasi Pérez, Daniel (Date of defense: 2013-02-27)
Several drug discovery approaches has been performed to find new compounds able to interact with high affinity with the hormone binding site of the homotetrameric protein transthyretin (TTR), and stabilize ...
Martín-Gago, Pablo (Date of defense: 2013-10-11)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family ...
Díaz Perlas, Cristina (Date of defense: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) ...
Fransen, Peter (Date of defense: 2013-12-05)
Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the ...
Adrián Izquierdo, Javier (Date of defense: 2012-09-28)
The indiscriminate and/or improper use of veterinary drugs is the cause of potential adverse health effects due to the risk of entering into the food chain and the appearance of residues in food products ...
Ros Simó, Enric (Date of defense: 2020-12-16)
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due ...
Defaus Fornaguera, Sira (Date of defense: 2014-06-20)
Glycosylation is a posttranslational modification affecting the fast majority of cellular surfaces through glycolipids and glycoproteins. It has been estimated that over 80% of all proteins are glycosylated ...
Fernández-Llamazares Onrubia, Ana Iris (Date of defense: 2013-12-09)
Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational ...