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Showing 10 out of a total of 53 results for collection: Departament de Química Orgànica. (3.806 seconds)
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(Date of defense: 09-12-2013)Backbone N-methylation is becoming an increasingly important tool in peptide drug design, and has been widely used to optimize the activity and selectivity of peptide ligands as a result of conformational modulation. ...
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(Date of defense: 28-09-2012)The indiscriminate and/or improper use of veterinary drugs is the cause of potential adverse health effects due to the risk of entering into the food chain and the appearance of residues in food products of animal origin. ...
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(Date of defense: 27-07-2015)Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant processing of Aß ...
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(Date of defense: 20-06-2014)Glycosylation is a posttranslational modification affecting the fast majority of cellular surfaces through glycolipids and glycoproteins. It has been estimated that over 80% of all proteins are glycosylated and that the ...
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(Date of defense: 15-02-2013)Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, it is a “head-to-side-chain” ...
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(Date of defense: 02-05-2013)The capacity of proteins to interact with each other rests at the core of biology. Given the ubiquitous nature of these interactions they have attracted the attention of scientists for the development of inhibitors or ...
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(Date of defense: 05-12-2013)Dendrimers are a class of globular highly branched macromolecules with precise architecture. They consist of a multivalent surface with functional group, a core unit where branching starts, and the interior is made of ...
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(Date of defense: 15-05-2015)The known as "difficult peptides", as well as those sequences that aggregate in solution, are some of those molecules with high applicability as nanomaterials or even in medicine field. This thesis has addressed to overcome ...
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(Date of defense: 23-09-2013)1. Introduction TomB/YmoB family of proteins was proposed as antitoxins of Hha/YmoA family of proteins. Toxin antitoxin (TA) systems are involved in the regulation of biofilm in bacteria, among other functions. Hha-TomB ...
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(Date of defense: 11-10-2013)Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...
