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Showing 6 out of a total of 6 results for collection: Departament de Química Orgànica. (0.385 seconds)

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Synthesis of Highly Structured and Receptor-Selective Tetradecapeptidic Analogs of Somatostatin: Fine-tuning the non-covalent interactions among their aromatic residues

Martín-Gago, Pablo (Date of defense: 11-10-2013)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally ...
Reactivity and Applications of New Substrates for the Intermolecular Pauson-Khand Reaction: N-Boc-propargylamines and trifluoromethyl alkynes

Aiguabella Font, Nuria (Date of defense: 07-02-2014)
The Pauson-Khand reaction (PKR) is, formally, a [2+2+1] cycloaddition involving an alkene, an alkyne and a carbon monoxide molecule, typically mediated or catalyzed by a cobalt (0) complex. The product of this reaction is ...
Intermolecular Pauson-Khad reaction: study of the regioselectivity, photochemistry of the adducts and synthetic applications

Khaizourane, Héléa (Date of defense: 11-03-2016)
The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated [2+2+1] ...
Development of synthetic strategies for lasso peptides with anticancer activity

Martín Gómez, Helena (Date of defense: 23-02-2018)
Nowadays, the discovery and development of novel constrained peptides which are likely to combine the advantages of therapeutic proteins with those of small molecules is of special interest. This has partially prompted ...
Syntheses of Protein Degraders and Compounds for Targeted Drug Release

Donoghue, Craig (Date of defense: 24-07-2019)
The thesis consists of two main projects: a) the development of a novel strategy to gain genetic control with spatiotemporal precision, and b) the optimisation of inhibitors of the protein kinase p38α, which has a major ...
Syntheses and applications of 3-bromo-1,2,4,5-tetrazines as novel tools for chemical biology

Ros Simó, Enric (Date of defense: 16-12-2020)
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due to their ability ...