Aiguabella Font, Nuria (Date of defense: 2014-02-07)
The Pauson-Khand reaction (PKR) is, formally, a [2+2+1] cycloaddition involving an alkene, an alkyne and a carbon monoxide molecule, typically mediated or catalyzed by a cobalt (0) complex. The product ...
Donoghue, Craig (Date of defense: 2019-07-24)
The thesis consists of two main projects: a) the development of a novel strategy to gain genetic control with spatiotemporal precision, and b) the optimisation of inhibitors of the protein kinase p38α, ...
Martín-Gago, Pablo (Date of defense: 2013-10-11)
Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family ...
Ros Simó, Enric (Date of defense: 2020-12-16)
The present doctoral thesis has been devoted to the use of 1,2,4,5-tetrazines as potential tools for chemical biology. Tetrazines have become extremely interesting functionalities due ...
Khaizourane, Héléa (Date of defense: 2016-03-11)
The Pauson-Khand reaction (PKR), introduced by Pauson and Khand in 1973, is an efficient method to access the synthesis of five-membered rings in one single step. This reaction is a transition metal-mediated ...
Martín Gómez, Helena (Date of defense: 2018-02-23)
Nowadays, the discovery and development of novel constrained peptides which are likely to combine the advantages of therapeutic proteins with those of small molecules is of special interest. This has ...