Now showing items 81-100 of 101

    Occurrence and distribution of organochlorinated pesticides and flame retardants in Spain and China 

    Zapata Corella, Pablo (Date of defense: 2022-09-19)

    In the present thesis, analytical methods based on gas chromatography coupled with mass spectrometry, both single (GC-MS) or tandem (GC-MS/MS), have been developed and optimized for the detection and quantification of ...

    Sorption of perfluoroalkyl substances and Fluoroquinolone antibiotics in matrices of environmental interest 

    Fabregat Palau, Joel (Date of defense: 2022-09-22)

    Perfluoroalkyl substances (PFASs) and fluoroquinolone antibiotics (FQs) are pollutants of environmental interest due to their widespread presence in environmental compartments and their high toxicity and disrupting effects ...

    Localized hypermutation and hypomutation in the genomes of human somatic cells 

    Mas-Ponte, David (Date of defense: 2022-11-14)

    [eng] Somatic cells accumulate mutations in their genome from a set of exogenous and endogenous processes. The interplay of DNA lesions and the DNA repair mechanisms in each cell shape the genetic mosaicism that composes ...

    Passive air and water sampling in high-altitude lakes: occurrence and distribution of legacy and emerging organic pollutants 

    Martínez Prats, Raimon (Date of defense: 2022-11-17)

    [eng] Remote high mountains allow the study of the environmental fate of legacy and emerging anthropogenic chemicals that form a worldwide diffuse background layer of pollution. Semi- volatile compounds like polychlorinated ...

    Design of peptides able to modulate Protein-protein interactions (PPIs) in mutated p53 

    Nicolini, Federica (Date of defense: 2022-12-02)

    [eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. On the contrary, ...

    Exploring protein structure changes due to somatic mutations in cancer 

    Diéguez Docampo, Andrea (Date of defense: 2023-03-02)

    [eng] Cancer is one of the most common diseases worldwide. Despite that a lot of time and resources have already been spent in this topic, there is still a long way to go to be able to cure every patient and improve their ...

    Tuning the composition and dimensionality of transition metal carbides as possible catalysts for green chemistry related reactions 

    López Berbel, Martí (Date of defense: 2023-03-03)

    [eng] Transition metal carbides (TMCs) have acquired a wide potential as a green chemistry catalysts. Their relatively high abundance and their catalytic performance makes them great candidates to replace scarce and pollutant ...

    Computational Modelling of the pH Effect on Intrinsically Disordered Proteins 

    Privat Contreras, Cristian (Date of defense: 2023-04-20)

    [eng] Intrinsically disordered proteins (IDPs) landed on the molecular biology framework at the turn of the 20th century to challenge the established protein function- structure paradigm. Due to their inherent flexibility ...

    Designing Advanced Nanocatalysts: Synthesis of complex CeO2-based Nanostructures 

    Hervés Carrete, Carmen (Date of defense: 2023-05-24)

    [eng] The main objective of this dissertation has been to stablish a bridge between materials science and its fields of application. The scope of this thesis work, under this premise, is aimed towards understanding the ...

    Agriculture-related organic contaminants: occurrence in edible crops, potential transfer from reclaimed water used for irrigation and bioremediation approaches 

    García Vara, Manuel (Date of defense: 2023-06-13)

    [eng] This doctoral thesis aims at providing novel analytical tools for the environmental control of CECs in waters and crops and generating new knowledge about i) the occurrence and fate of CECs in the agricultural ...

    MXene Materials for CO(2) Capture and Transformation 

    Jurado Mañas, Anabel (Date of defense: 2023-06-21)

    [eng] MXene materials, the low-dimensional counterpart of transition metal carbides and nitrides present suitable properties as catalysts in heterogeneous catalysis given the similar properties with transition metal carbides ...

    Liberación de partículas atmosféricas en escenarios industriales reales y su impacto en la exposición humana y ambiental. Casos de estudio: actividades portuarias y reciclaje de residuos electrónicos 

    López Olivé, Maria (Date of defense: 2023-09-15)

    [spa] Los estudios sobre exposición a nanopartículas (NP) en aerosoles atmosféricos son cada vez más importantes para comprender sus efectos en la salud humana y el medio ambiente, ya que las NP pueden penetrar profundamente ...

    Design and Synthesis of Bifunctional Compounds for Targeted Protein Degradation and Phosphorylation 

    Loren Parrondo, Guillem (Date of defense: 2023-09-15)

    [eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing the phosphorylation ...

    From Romanesque to Gothic: A compositional, morphological and formal study of medieval cultural heritage objects 

    Magkanas, Georgios (Date of defense: 2023-09-18)

    [eng] The present PhD thesis is focused on the study of the compositional, morphological and formal characteristics of medieval cultural heritage objects, and more specifically manuscripts and champlevé enamels of Limoges, ...

    Forefront cold spray additive manufacturing development by leveraging new spraying strategies 

    Vaz, Rodolpho Fernando (Date of defense: 2023-10-27)

    [eng] Additive manufacturing (AM) is a process of creating a physical object by adding material layer by layer rather than removing material through machining. It is also known as 3D printing, as it typically involves using ...

    Multiscale modelling of CO2 hydrogenation reactions on Ni-based catalysts 

    Lozano Reis, Pablo (Date of defense: 2023-11-10)

    [eng] Global warming and climate change, mostly due to the increasing concentration of greenhouse gases in the atmosphere, are producing devastating effects. Among the different greenhouse gases, CO2 is one of the major ...

    Non-coding genome functions in cancer 

    Subirana Granés, Marc (Date of defense: 2023-11-17)

    [eng] Historically, cancer genomics has predominantly focused on coding regions. Current knowledge suggests that non-coding mutations are likely crucial in driving the mechanisms that regulate gene activity, potentially ...

    Computational modelling to study medium effect over molecules and biopolymers of interest in biomedicine 

    Barazorda Ccahuana, Haruna Luz (Date of defense: 2023-11-17)

    [eng] Computational simulation technologies facilitate the resolution of complex biomedical problems by helping researchers predict what will happen in a natural system in response to various external conditions. The main ...

    Anaerobic digestion of animal by-products: assessment of process limitations and opportunities in real pig slaughterhouses 

    Otero Rodríguez, Ana Mª (Date of defense: 2023-11-28)

    [eng] Meat industry and particularly pig slaughterhouses produce huge amounts of animal by- products not intended for human consumption. This residual stream appears as a potential raw material for anaerobic digestion and ...

    Desarrollo y evaluación de análogos de C75 como potenciales fármacos contra la obesidad y el cáncer 

    Gómez García, Roberto (Date of defense: 2023-12-15)

    [spa] La presente Tesis de carácter multidisciplinar se centra en el diseño y síntesis de nuevos derivados de C75 como potenciales agentes antitumorales e inhibidores de la ingesta para el desarrollo de nuevos fármacos ...