Now showing items 1-3 of 3
Mas-Ponte, David (Date of defense: 2022-11-14)
[eng] Somatic cells accumulate mutations in their genome from a set of exogenous and endogenous processes. The interplay of DNA lesions and the DNA repair mechanisms in each cell shape the genetic mosaicism that composes ...
Alagia, Adele (Date of defense: 2015-12-11)
To direct post-transcriptionally gene silencing, RNAi machinery exploits the formation of base pairs between the loaded guide strand and the complementary mRNA. The Ago2 protein is the “slicer” effector of the RISC and ...
Subirana Granés, Marc (Date of defense: 2023-11-17)
[eng] Historically, cancer genomics has predominantly focused on coding regions. Current knowledge suggests that non-coding mutations are likely crucial in driving the mechanisms that regulate gene activity, potentially ...