Mostrando ítems 1-15 de 15
Gómez García, Roberto (Fecha de defensa: 2023-12-15)
[spa] La presente Tesis de carácter multidisciplinar se centra en el diseño y síntesis de nuevos derivados de C75 como potenciales agentes antitumorales e inhibidores de la ingesta para el desarrollo de nuevos fármacos ...
Loren Parrondo, Guillem (Fecha de defensa: 2023-09-15)
[eng] In this doctoral thesis, the design and synthesis of bifunctional molecules that induce the degradation of a target protein in cells are described. The synthesis of molecules capable of inducing the phosphorylation ...
Nicolini, Federica (Fecha de defensa: 2022-12-02)
[eng] Protein-protein interactions (PPIs) play a crucial role in the homeostasis of the cells; therefore, they are important therapeutic targets. Typically, the goal in targeting PPIs is to impede them. On the contrary, ...
Riefolo, Fabio (Fecha de defensa: 2020-07-29)
Modern medical treatments are largely based on the ability of pharmacological drugs to interact with a molecular target in the human body (e.g., receptors) in order to evoke a physiological response. Such targets are ...
Santiago Piera, Raul (Fecha de defensa: 2024-02-16)
[eng] Organic chemistry is recognized for its ability to arrange a limited set of atoms in numerous ways, a quality that is crucial in molecular magnetism. This branch benefits from the adaptability of organic chemistry ...
Mendive Tapia, Lorena (Fecha de defensa: 2017-02-17)
In the present thesis we have investigated the development of new methodologies for the selective and straightforward chemical modification of Trp amino acid either alone or in peptides. In the first chapter, we have ...
Borràs Tudurí, Roser (Fecha de defensa: 2018-07-06)
The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to defense the body against threatens. IS is organized into two lines of defense: innate immunity which acts in a non-specific manner ...
Panarello, Silvia (Fecha de defensa: 2021-12-15)
Photopharmacology has the main purpose to allow the control of protein activity with light. The most exploited strategy used to achieve this objective is the freely diffusible photopharmacology and it is based in the use ...
Puig Gomà-Camps, Eduard (Fecha de defensa: 2019-06-20)
Alzheimer’s disease (AD) is the most common form of dementia. It was first described in 1906 by Alois Alzheimer. Later on, in 1984 George Glenner and Colin Masters isolated the amyloid-beta (Aβ) peptide from a human brain ...
Gil Escolano, Alejandro (Fecha de defensa: 2018-02-16)
Marine natural products (MNPs) are, undoubtedly, highly valuable starting points for drug-development programs. Generally, MNPs show a well-defined spatial orientation that have evolved for thousands of years to interact ...
Matarín Morales, Joan Antoni (Fecha de defensa: 2021-12-15)
Peptides are defined as compounds that contain between two and fifty amino acids connected together by amide bonds. Inside our body, peptides are natural biological messengers that play critical roles in human physiology ...
Palà Pujadas, Judith (Fecha de defensa: 2018-03-12)
Chemical protein synthesis has become a potent tool for the synthesis of proteins, especially those which are not easily accessed by DNA recombinant methods, such as proteins with posttranslational modifications. The key ...
Zamudio Vázquez, Rubí (Fecha de defensa: 2014-02-14)
Triostins are members of the quinoxaline antibiotic family, together with the "prototypical bisintercalator" echinomycin. These molecules display interesting antitumour activities as they inhibit transcription through ...
Frigolé Vivas, Marta (Fecha de defensa: 2020-09-23)
[eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to proteins, otherwise ...
Ninot Pedrosa, Martí (Fecha de defensa: 2018-03-02)
Amyloid-beta peptide (Aβ) is strongly linked to the aetiology of Alzheimer’s disease (AD). Aβ is the main component of the amyloid plaques found in the brain of AD patients, however, Aβ is also present in the brain of ...