Now showing items 41-60 of 101

    Synthesis of Sonic Hedgehog protein and development of peptide binders using phage display libraries 

    Palà Pujadas, Judith (Date of defense: 2018-03-12)

    Chemical protein synthesis has become a potent tool for the synthesis of proteins, especially those which are not easily accessed by DNA recombinant methods, such as proteins with posttranslational modifications. The key ...

    Assessment of the lipidomic effects of environmental pollutants on exposed organisms using chemometric and analytical methods 

    Gorrochategui Matas, Eva (Date of defense: 2018-04-20)

    Lipidomics is a subset of metabolomics, which in turn, is one of the categorical platforms that constitute omics. Omic sciences aim at the study of the abundance and (or) structural characterization of a broad range of ...

    Non-glycosidic analogues of alpha-galactosylceramide: Design, synthesis and biological activity 

    Borràs Tudurí, Roser (Date of defense: 2018-07-06)

    The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to defense the body against threatens. IS is organized into two lines of defense: innate immunity which acts in a non-specific manner ...

    Development and application of Nuclear Magnetic Resonance spectroscopy and chemometric methods for the analysis of the metabolome of Saccharomyces cerevisiae under different growing conditions 

    Puig Castellví, Francesc (Date of defense: 2018-07-10)

    Nuclear Magnetic Resonance (NMR) spectroscopy is able to produce by a single direct measurement a very high amount of chemical information. However, this information is not always easy to interpret. In fact, the complexity ...

    Information Transfer and Dynamics of Nucleic Acids studied by Theoretical Approaches 

    Balaceanu, Alexandra (Date of defense: 2018-12-12)

    1. The Force Field Accuracy Problem. The utility and applicability of MD simulations to model biomolecular systems goes only as far as its ability to sufficiently sample the conformational space and the correct description ...

    3d and/or 4f coordination compounds derived from chiral Schiff bases: magnetic and spectroscopic study 

    Mayans Ayats, Júlia (Date of defense: 2018-12-14)

    This PhD thesis has been developed in the Molecular Magnetism Group of the University of Barcelona. As its name indicates, the Molecular Magnetism Group is mostly interested in the magnetic study of coordination complexes, ...

    Deposition of environmentally friendly cermets coatings by thermal spray techniques 

    Bazyaran, Fatemeh (Maryam) (Date of defense: 2019-04-01)

    The main objective of this research work was to produce environmentally friendly cermets coatings, Ni and Co free matrix, alternative to conventional WC- Co, by thermal spray processes. WC-Co cermets has always been one ...

    Structural characterization of amyloid beta oligomers with functional links associated to Alzheimer's disease 

    Puig Gomà-Camps, Eduard (Date of defense: 2019-06-20)

    Alzheimer’s disease (AD) is the most common form of dementia. It was first described in 1906 by Alois Alzheimer. Later on, in 1984 George Glenner and Colin Masters isolated the amyloid-beta (Aβ) peptide from a human brain ...

    An integrated assessment of nanoparticle exposures in the ceramic industry 

    Salmatonidis, Apostolos (Date of defense: 2019-09-30)

    Exposure to nanoparticles has been associated with adverse effects on human health. When the exposure route is inhalation, nanoparticles can cause pulmonary inflammation which may be more severe than from fine particles, ...

    Organic pollutants in indoor dust: method development, site-specific monitoring and human exposure 

    Velázquez Gómez, Miquel (Date of defense: 2019-10-21)

    Dust has been used as a surrogate of indoor organic contamination for several decades. Their concerns for human health include from sensitization effects such as allergies to toxic effects derived from those organic ...

    Contaminants organoclorats, organobromats i organofosforats en població general 

    Bravo Villarraso, Natalia (Date of defense: 2019-11-21)

    Durant les dècades dels anys 50 i 60 del segle XX es van utilitzar arreu del món diferents tipus de compostos organoclorats i organobromats, que pertanyen als contaminants orgànics persistents (COPs), com a pesticides, ...

    Análisis cualitativo y cuantitativo de fármacos en peces por espectrometría de masas de alta resolución de cuadrupolo-tiempo de vuelo 

    Peña Herrera, Juan Manuel (Date of defense: 2020-05-04)

    En la presente tesis doctoral se desarrollaron métodos analíticos para la determinación de fármacos de uso humanos en el tejido muscular de los peces, incluyendo la comparación y optimización de diferentes tipos de ...

    Chemical and ecotoxicological assessment of microplastics and emerging risks in the coastal environments 

    Schirinzi, Gabriella Francesca (Date of defense: 2020-06-10)

    In recent decades, global plastics production and consumption have continued to increase. Although many policy strategies on waste prevention and recycling have been implemented, much of the plastic waste is dispersed in ...

    Development and applications of photoswitchable muscarinic ligands 

    Riefolo, Fabio (Date of defense: 2020-07-29)

    Modern medical treatments are largely based on the ability of pharmacological drugs to interact with a molecular target in the human body (e.g., receptors) in order to evoke a physiological response. Such targets are ...

    Targeting the disordered N-terminal domain of androgen receptor. Novel inhibitors tackling biomolecular condensation to treat late stage prostate cancer 

    Frigolé Vivas, Marta (Date of defense: 2020-09-23)

    [eng] Drug discovery is the process by which new drugs are found and developed into the market. Given the scope of this thesis, the term “drug” will refer to small molecules and the term “target” to proteins, otherwise ...

    Conformational catalytic itineraries of five- and six-membered sugar rings in enzymatic and superacid media 

    Nin Hill, Alba (Date of defense: 2020-10-26)

    Carbohydrates were early considered important for energy storage and structural support for living organisms. It was not until a few decades ago that scientist discovered that they are also involved in much more complex ...

    Drogas y psicofármacos: estudio de su presencia en el medio ambiente (aguas residuales, sedimentos y mejillones) y evaluación de su consumo e impacto 

    López García, Ester (Date of defense: 2021-01-27)

    En esta tesis doctoral se han desarrollado tres metodologías analíticas para el análisis de drogas, psicofármacos y sus metabolitos en tres compartimentos medioambientales: aguas residuales, sedimentos y biota. Las ...

    Pesticides in the environment: analysis, occurrence, impact and recommendations for their attenuation 

    Barbieri, Maria Vittoria (Date of defense: 2021-01-28)

    The assessment of pesticide occurrence in different environmental compartments has become a matter of outstanding importance since its effects on exposed organisms may be considered a warning on the potential risk these ...

    Evaluation of biotoxins in marine ecosystems by new analytical and biological strategies 

    Bosch Orea, Cristina (Date of defense: 2021-01-29)

    In this thesis is presented the development of different analytical methodologies for the analysis of marine biotoxins in seawater. The objectives were the development of the methods and the application to study the biotoxins ...

    Suspect screening of natural toxins in surface water reservoirs 

    Picardo, Massimo (Date of defense: 2021-02-04)

    Natural toxins include a multitude of toxic secondary metabolites produced by animals, bacteria, fungi algae, and plants that are generally not intended as environmental contaminants of concern for water quality. However, ...