Facultat de Química: Recent submissions
Now showing items 81-100 of 103
Espectrometría de masas de alta resolución y en tándem. Análisis de alto rendimiento de contaminantes orgánicos emergentes en agua
En los últimos años, los contaminantes emergentes (ECs) están recibiendo una creciente atención debido a los efectos nocivos que suponen para los organismos vivos y al riesgo ambiental que representan. Existen una gran ...
Modulation of the RNAi pathway by chemically modified siRNA molecules
To direct post-transcriptionally gene silencing, RNAi machinery exploits the formation of base pairs between the loaded guide strand and the complementary mRNA. The Ago2 protein is the “slicer” effector of the RISC and ...
An STM/FM-AFM investigation of selected organic and inorganic 2D systems on metallic surfaces
Organic/inorganic interfaces play a key role in organic electronic devices such as organic light emitting diodes (OLED), organic field effect transistors (OFET) and organic solar cells (OSC). In these interfaces crucial ...
Evaluación del impacto ambiental asociado al uso de nuevos retardantes de llama
Los retardantes de llama halogenados (HFRs) se aplican a una gran variedad de materiales, como muebles, textiles, material electrónico, etc., con el objetivo de prevenir los incendios. La demanda global se incrementa año ...
Drogues d’abús i fàrmacs en el medi aquàtic: Anàlisi, presencia i comportament
Les drogues d'abús i els fàrmacs estan considerats com contaminants d'interès emergent en el medi aquàtic, és a dir, són substàncies que no estan incloses en els programes habituals de control i monitorització d'aigües, ...
Estudi de plastificants en mostres d’aigua i begudes
Els plastificants són additius o monòmers dels plàstics que s'empren durant la fabricació d'aquests per modificar propietats fisicoquímiques. Poden arribar al medi ambient a partir de focus industrials, ja que són produïts ...
Disulfide-based dynamic combinatorial libraries of macrocyclic pseudopeptides as bio-inspired complex chemical systems
Dynamic combinatorial chemistry proposes the creation of a library of compounds (dynamic combinatorial library, DCL) inter-connected through reversible chemical processes. The concentrations in a DCL are determined by ...
Estudio de emulsiones altamente concentradas de tipo W/O: relación entre tamaño de gota y propiedades
Las emulsiones son dispersiones de dos líquidos inmiscibles que, generalmente están estabilizadas por moléculas tensioactivas. Cuando la fracción en volumen de fase dispersa es superior o igual a 0,74 (valor que corresponde ...
Application of chemometrics to hyperspectral imaging analysis of environmental and agricultural samples
This Thesis deals with the resolution of hyperspectral imaging data by using chemometric methods, in particular by using appropriate data pretreatment methods and by using Multivariate Curve Resolution (MCR) methods. The ...
Formación y propiedades de espumas macroporosas de quitosano obtenidas a partir de emulsiones altamente concentradas
El principal objetivo de la presente tesis es la obtención de espumas de quitosano mediante la utilización de emulsiones altamente concentradas de tipo aceite en agua (O/W). Para alcanzar dicho objetivo, este trabajo ha ...
Protein Flexibility: From local to global motions. A computational study
Proteins are flexible entities, and thus move. Its function is closely related to the flexibility. To carry out any function is necessary a conformational change. As protein motions imply an exchange of conformations, ...
Crystal Engineering Studies of Squaric Acid Derivatives
This thesis is a multidisciplinary study of the solid state of squaric acid derivatives which combines approaches from areas such as crystal engineering, supramolecular chemistry and crystallography. The structural preferences ...
Cold Spray Deposition of WC-Co Cermets
The main subject of this Thesis is the production of hard, wear and corrosion resistant cermets tungsten carbide and cobalt cermets (WC-Co) with different contents in cobalt matrix, onto low carbon steels and aluminum alloy ...
Textiles funcionales obtenidos a partir de la incorporación de nanopartículas poliméricas
El objetivo principal de la presente tesis es el diseño de nanopartículas de etilcelulosa para su utilización como vehículos de principios activos o sustancias lipofílicas y su deposición sobre un tejido, con la finalidad ...
Study of the aggregation process of the amyloid beta-protein associated to Alzheimer's disease. Examination of pharmaceutically important small molecules.
Alzheimer’s disease (AD) is a neurodegenerative disorder which major risk factor is age. Current drugs only offer symptomatic alleviation in AD, thus a disease-modifying treatment is urgent. The amyloid-β (Aβ) protein ...
Small molecules for modulating biological targets
CHAPTER 1: Respiratory Infectious Diseases (RID) are diseases affecting the air passages, the bronchi and the lungs. They range from acute infections, such as pneumonia and bronchitis, to chronic conditions such as ...
Formación y caracterización de emulsiones altamente concentradas de betún en agua
El objetivo principal de la presente tesis ha sido la preparación y caracterización de emulsiones bituminosas concentradas y altamente concentradas de betún en agua controlando el tamaño de gota. Las investigaciones y ...
Protease inhibitors as therapeutic agents
Proteases are involved in a high number of diseases, and thus, are relevant targets. For that reason our main goal was the discovery of protease inhibitors as therapeutic agents. We focused our study in four proteases: ...
Novel Disulfide Formation Strategies in Peptide Synthesis
Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...
Chemically synthesized peptide libraries as a new source of BBB-shuttles. Use of Mass Spectrometry for peptide identification and quantification
The blood-brain barrier (888) is a biological barrier that plays a crucial role protecting the brain from neurotoxic agents and regulating the influx and efflux of molecules required for the correct function of this organ. ...
