Implication of Long-Chain Fatty Acids in Glucose-Induced Insulin Secretion in the Pancreatic Beta-Cell 

    Herrero Rodríguez, Laura (Date of defense: 2004-11-24)

    INTRODUCTION Carnitine palmitoyltransferase I, which is expressed in the pancreas as the liver isoform (LCPTI), catalyzes the rate-limiting step in the transport of fatty acids into the mitochondria for their oxidation. ...

    Regulation of E2F1 Transcription Factor by Glycogen Synthase Kinase-3-Beta 

    Garcia Alvarez, Gisela (Date of defense: 2005-03-10)

    Whether a cell enters the cell cycle, undergoes apoptosis or survives is a consequence of the integration of several cellular and environmental signals. Growth factors, cell contact, and apoptotic inductors regulate a ...

    Paper de la UGT1A6 en la resistència al metotrexat : estudi dels harpins de polipurines per disminuir l'expressió gènica 

    Almagro García, Ma. Cristina de (Date of defense: 2010-12-13)

    El treball presentat en aquesta memòria es centra en l'estudi dels mecanismes pels quals el quimioteràpic metotrexat (MTX) desenvolupa resistència en cèl·lules canceroses. Dins d'aquest objectiu es creen dues línies d'estudi ...

    Molecular characterization of carnitine palmitoyltransferase 1C 

    Gratacòs Batlle, Esther (Date of defense: 2010-12-16)

    Carnitine palmitoyltransferase 1 (CPT1) catalyzes the conversion of long chain fatty acyl-CoAs into acylcarnitines, the first step in the transport of long chain fatty acids from the cytoplasm to the mitochondrial matrix, ...