Carreras Cardona, Anna (Date of defense: 2012-05-04)
During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical ...
Brugarolas Campillos, Marc (Date of defense: 2013-12-20)
The aims of this thesis are: Aim 1. The involvement of A(1)R-A(2A)R heteromer in glial cells and its study at a molecular level. Aim 2. To find evidence for allosteric interactions between partner ...
Martinez Cristobal, Paula (Date of defense: 2016-12-01)
Protein homeostasis (proteostasis) results from the fine regulation of synthesis and degradation. The nuclear cofactor DOR/TP53INP2 was identified originally as a protein expressed in PML of nuclear ...
Jayaraman, Anusha (Date of defense: 2016-07-05)
Angiogenesis is the formation of blood vessels from the pre-existing ones and is required for distributing nutrients and oxygen to the tissues through the blood flow. This process is important for tumour ...
Testoni, Giorgia (Date of defense: 2016-02-05)
Glycogen synthesis is crucial for storing glucose residues that are released in case of energy demand. The mechanism needs to be tightly regulated because a lack or an overload of glycogen can lead to ...
Pérez Verdaguer, Mireia (Date of defense: 2015-01-26)
The voltage-dependent K+ channel Kv1.3 participates in many physiological events like proliferation and activation of immunitary cells, membrane repolarization in sensory neurons, vascular smooth muscle ...
Vallejo Gracia, Albert (Date of defense: 2016-04-15)
Voltage dependent potassium channels are a group of plasma membrane ion channels with a key role in the immune system as the predominant ion channels controlling the resting membrane potential and tuning ...
Niisuke, Katrin (Date of defense: 2013-07-10)
Neuregulin (NRG), which structurally belongs to an EGF family of growth factors, activated in acute manner signaling cascades that lead to changes in whole-body glucose metabolism in fasted mice. Besides ...
Polat, Ibrahim H. (Date of defense: 2016-11-04)
In this thesis, tumor metabolic reprogramming has been exploited in order to propose new targets in cancer treatment. On one hand, we explored the pentose phosphate pathway (PPP) enzymes as putative ...
Pérez Cano, Laura (Date of defense: 2013-06-28)
Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, ...