Isasa Catalán, Marta (Date of defense: 2012-07-19)
Targeted protein degradation plays a central role in eukaryotic cell regulation and homeostasis. The ubiquitin proteasome system (UPS) is involved in a large number of cellular events, being, day by ...
Roig Merino, Sara Raquel (Date of defense: 2017-05-05)
Voltage-gated potassium channels are proteins that allow the flux of potassium ions across the plasma membrane in response to a voltage stimulus. Those proteins were initially described in nervous system ...
Rodríguez Lumbreras, Luis Ángel (Date of defense: 2023-04-18)
[eng] The study of the 3D structural details of protein-protein and protein-DNA interactions is essential to understand biomolecular functions at the molecular level. Given the difficulty of the structural ...
Marín de Mas, Igor Bartolomé (Date of defense: 2015-03-20)
The general aim of this thesis is to develop and apply new computational tools to overcome existing limitations in the analysis of metabolism. This thesis is focused on developing new computational ...
Álvarez Marimón, Mª Elena (Date of defense: 2014-10-27)
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide ...
Arimany Nardi, Cristina (Date of defense: 2013-12-03)
Nucleoside-derived drugs are used for the treatment of haematological malignancies, viral infections and autoimmune or inflammatory diseases. These drugs require membrane transporters to be internalised ...
Benito Mauricio, Adrián (Date of defense: 2014-02-21)
The present doctoral thesis is focused on the metabolic adaptations induced by oncogene activation as well as the potential role of the metabolic network as antitumor therapy. Over the last years, it ...
Codó Tarraubella, Laia (Date of defense: 2019-12-03)
Recently, research processes in Life sciences have evolved at a rapid pace. This evolution, mainly due to technological advances, offers more powerful equipment and generalizes the digital format of ...
Rotondo, Floriana (Date of defense: 2018-02-19)
The current theories about endothelial inflammation in the adipose tissue in metabolic syndrome point to hypoxia as one of its main causes. Nevertheless, our group has found that both 3T3L1 adipocytes, ...
Giménez Oya, Víctor (Date of defense: 2009-12-09)
Los isoprenoides son una de las mayores familias de compuestos descritos en la naturaleza. Estos compuestos están presentes en todos los organismos vivos y se sintetizan a partir de dos moléculas de 5 ...