Regulation of self-renewal in colorectal cancer cell models 

    Meca-Cortés, Oscar (Fecha de defensa: 2014-12-17)

    The transcription factor SOX2 is a key determinant of stem cell properties, also involved in the initiation, maintenance and progression of several human cancers. By studying the in vitro phenotypic ...

    Relació estructura-funció de les proteïnes CPT1 

    Pujol Vidal, Maria Magdalena (Fecha de defensa: 2012-07-17)

    L’enzim Carnitina palmitoïltransferasa 1 (CPT1) permet l’entrada dels àcids grassos de cadena llarga a la matriu mitocondrial per tal de ser degradats i utilitzats així com a substrat energètic. El malonil-CoA, primer ...

    Resistance to HIV entry inhibitors: signature mutations as tool guide for the identification of new antiviral agents 

    González-Ortega, Emmanuel (Fecha de defensa: 2012-07-23)

    There are several reasons to celebrate the latest advances in the treatment of the infection with HIV. According to the Joint United Nations Programme on HIV/AIDS, the number of new infections dropped by 15%; there is also ...

    Resistencia a la insulina inducida por acidos grasos en células de músculo esquelético L6E9: papel de la carnitina palmitoiltransferasa I (CPT-I) 

    Sebastián Muñoz, David (Fecha de defensa: 2006-03-31)

    La resistencia a la insulina es un estado patológico que se define como la incapacidad del organismo de responder normalmente a las acciones de la insulina. Este estado está ligado a la obesidad, al estilo sedentario de ...

    Role of Notch/RBPjk signaling pathaway in embryonic hematopoiesis 

    Robert Moreno, Alexandre (Fecha de defensa: 2007-09-28)

    The process that gives rise to all the mature blood cells from the HSCs (Hematopoietic Stem Cells) is known as hematopoiesis. In the adult, hematopoiesis takes place in the bone marrow although the HSCs are likely generated ...

    Role of the Kinases NEK6, NEK7 and NEK9 in the Regulation of the Centrosome Cycle 

    Sdelci, Sara (Fecha de defensa: 2012-12-13)

    This thesis project is focused on the study of the signaling module formed by the NIMA-related protein Nek6, Nek7, and Nek9 and their function during early mitosis, with particular interest in centrosome separation and ...

    Role of the tumour suppressor pathway p53‐p21 in the regulation of metabolism 

    Pulice, Giuseppe (Fecha de defensa: 2014-12-15)

    Changes in diet and life style caused an alarming increase in the incidence of obesity, which is considered a major risk factor for the onset of the metabolic syndrome. One of the initial events in obesity is adipocyte ...

    Search for new antiviral compounds using fragment screening methodology 

    Kaczmarska, Zuzanna (Fecha de defensa: 2014-12-05)

    Picornaviridae are among the most diverse and oldest known viral families that include many important pathogens of humans and animals. They are small, icosahedral (+)ssRNA viruses, causing a variety of diseases, such as ...

    Síndrome de cáncer de mama y ovario hereditario: Estudio in vitro de variantes BRCA1 y BRCA2 de significado biológico desconocido y búsqueda de nuevos genes responsables de este síndrome 

    Quiles Vidal, Francisco de Asís (Fecha de defensa: 2016-02-05)

    ANTECEDENTES: Entre un 20-25% de pacientes con cáncer de mama y ovario muestran historia familiar de dicha enfermedad. Una porción de estos casos son debidos a mutaciones germinales en genes de predisposición conocidos y ...

    Structural and functional analysis of natural protein-based inhibitors and their protease targets 

    dos Reis Mendes, Soraia Inês (Fecha de defensa: 2022-10-28)

    [eng] Several proteases and their antagonistic protein or peptide inhibitors sparked researchers’ interest due to their potential as therapeutic targets. The present thesis, which compiles results obtained in three independent ...

    Study of carnitine palmitoyltransferase 1A (CPT1A) in adipose tissue. Effects on obesity, inflammation and insulin resistance 

    Malandrino, Maria Ida (Fecha de defensa: 2013-10-04)

    Current lifestyle with high-energy diets and little exercise is triggering an alarming growth in obesity. Excess of adiposity is leading to severe increase in associated pathologies, such as insulin resistance, type ...

    Study of the molecular mechanisms responsible for E2F1-induced Mtorc1 activation 

    Meo Evoli, Nathalie (Fecha de defensa: 2014-07-07)

    The oncogenic properties of E2F1 have been traditionally associated with the role of the oncogene in proliferation, but during the last few years many other functions associated with this family of transcription factors ...

    Study of the phosphorylation and activation of the protein kinase NEK9 during mitosis 

    Bertran Domingo, M. Teresa (Fecha de defensa: 2012-11-29)

    Nek9 is a NIMA-related kinase that is phosphorylated in mitosis and a small pool of it (5%) is activated at the centrosomes by a complex mechanism which has remained elusive until now. Nek6 and Nek7 bind to the C-terminal ...

    Study of the physiological function of carnitine palmitoyltransferase 1C enzyme 

    Carrasco Rodríguez, Patricia (Fecha de defensa: 2012-03-16)

    Carnitine palmitoyl transferase 1 (CPT1) enzymes catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, thus facilitating the entry of long-chain fatty acids to the mitochondria, where they undergo β-oxidation. ...

    Systematic identification and quantification of substrate specificity determinants in human protein kinases = Identificación y cuantificación sistemática de determinantes de la especificidad por sustrato en las proteínas quinasas de humano 

    Alonso Tarajano, Manuel Alejandro (Fecha de defensa: 2013-10-24)

    In human there are 518 protein kinases reported and many of them are involved in several cellular processes and also in important pathologies. Kinases have a diverse specificity for the sequences they phosphorylate, and ...

    The structure and function of maize scutellum during early stages of germination 

    Tnani, Hédia (Fecha de defensa: 2012-07-18)

    The embryo in grasses, at grain maturity, comprises the embryonic axis and the scutellum. The scutellum is supposed to be the single cotyledon in the monocotyledoneus embryos and is attached to the embryo axis in the ...