Fajardo Calderón, Carlos Alberto (Date of defense: 2017-05-19)
Oncolytic adenoviruses that selectively replicate in cancer cells while sparing normal tissue have gained considerable attention as novel anticancer drugs. However, clinical trials with these viruses ...
Ventura Ventanachs, Verònica (Date of defense: 2013-10-18)
Irosustat is a first-generation, irreversible, steroid sulfatase inhibitor currently in development for hormone-dependent cancer therapy. Its structure is a tricyclic coumarin-based sulfamate that ...
Robles García, Virginia (Date of defense: 2014-12-05)
Clathrin is an evolutionary conserved molecule that coats membranes endocytosed from the plasma membrane and those that move between the trans-Golgi network (TGN) and endosomes of eukaryotic cells. It ...
Rojas Expósito, Luis Alfonso (Date of defense: 2017-05-26)
Cancer virotherapy with oncolytic adenoviruses represents a promising therapeutic approach due to the capacity of these viruses to infect and selectively kill tumor cells without damaging normal tissues. ...
Rodríguez Banqueri, Arturo (Date of defense: 2013-03-14)
X-ray crystallography is, now at days, one of the most powerful techniques to study proteins at the atomic level. Unfortunately, obtaining high quality crystals of membrane proteins for x-ray diffraction ...
González-Ortega, Emmanuel (Date of defense: 2012-07-23)
There are several reasons to celebrate the latest advances in the treatment of the infection with HIV. According to the Joint United Nations Programme on HIV/AIDS, the number of new infections dropped ...
Kaczmarska, Zuzanna (Date of defense: 2014-12-05)
Picornaviridae are among the most diverse and oldest known viral families that include many important pathogens of humans and animals. They are small, icosahedral (+)ssRNA viruses, causing a variety of ...
Villalobos Alberú, Xenia (Date of defense: 2015-12-22)
This work is focused on the study of the stability and immunogenic properties of the Polypurine Reverse Hoogsteen hairpins (PPRHs), and on their use as a gene-silencing tool. PPRHs are non-modified DNA ...
Hospital Gasch, Adam (Date of defense: 2014-10-13)
Macromolecular structure, and, specifically, its dynamics and flexibility, play a crucial role in its final biological function. Intense efforts are being made to obtain experimental information about ...
Rodríguez Gallego, Laura (Date of defense: 2015-03-13)
The work presented in this thesis is focused on the study of Polypurine Reverse Hoogsteen hairpins (PPRHs) as gene silencing tools. PPRHs are double-stranded DNA molecules formed by tvvo anti parallel ...