Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest 

    Lupala, Cecylia Severin (Date of defense: 2016-01-28)

    GPCR are integral membrane receptor proteins that are characterized by heptahelical transmembrane domains connected by intracellular and extracellular loops. GPCRs are an attractive class of proteins for drug discovery, ...

    Fate and effects of waterborne contaminants of emerging concern in the soil-plant system : impact of biochar soil amendment to mitigate their plant uptake 

    Hurtado Cervera, Carlos (Date of defense: 2017-07-14)

    Water scarcity is an issue of global concern due to the increase of the population and the climate change, which both increase the water demand. Many arid and semiarid countries are facing high water stress and the use of ...

    Influence of agricultural practices on the microbiome and the antibiotic resistance gene complement in soils, plants, and crops 

    Cerqueira, Francisco Diogo de Almeida (Date of defense: 2020-06-08)

    Antibiotic (AB) Resistance is an increasing global problem for public health, with multi-resistant bacteria persisting and spreading not only in clinical settings but also in the environment. One of the possible vectors ...

    Stability and ligand binding properties of human cone visual pigments 

    Srinivasan, Sundaramoorthy (Date of defense: 2015-10-02)

    Human color perception is mediated by cone photoreceptor cells which mainly locate on the fovea of the eye. Bright light activates the photosensitive opsin pigments which are embedded in the outer segment membrane discs ...

    Structure-activity investigation on laccases by computational and site directed mutagenesis studies 

    Delavari, Azar (Date of defense: 2016-12-01)

    Laccases belong to multi copper oxidase enzyme family (EC 1.10.3.2). Their capacity to oxidíze a wide range of substrates makes them very attractive for the industry and are growing in importance for environmentally-friendly ...

    Structure-function relationships in sensory G protein-coupled receptors 

    Razzaghi, Neda (Date of defense: 2022-11-25)

    (English) Perception of the world by an organism is not possible unless decoding the received information through its sensory systems. In vertebrates, G-protein-coupled receptors (GPCRs) and ion channels are principal ...

    Structure-function studies of bombesin and bradykinin receptors and their ligands for new therapeutic opportunities 

    Rasaeifar, Bahareh (Date of defense: 2020-12-10)

    G-protein coupled receptors represents the largest family of membrane protein in eukaryotes cells with more than 800 members. The reason of their importance lies in their function, being responsible for the primary mechanism ...